Figure 3From: The changing clinical profile of celiac disease: a 15-year experience (1998-2012) in an Italian referral center Gastrointestinal and extraintestinal symptoms in 770 CD patients. A) Symptoms related to gastrointestinal tract included diarrhea (27%), bloating (20%), aphthous stomatitis (18%), alternate bowel habit (15%), constipation (13%) and gastroesophageal reflux disease (GERD) (12%). B) Extraintestinal manifestations, alone or in combination with gastrointestinal symptoms/signs, included osteopenia/osteoporosis (52%), anemia (34%), cryptogenic hypertransaminasemia (29%), recurrent miscarriages (12%), IgE-mediated allergy (9%), headache (5%) and fibromyalgia-like symptoms (2.2%).Back to article page