From: Evaluation of the role of HLA-DR antigens in Japanese type 1 autoimmune hepatitis
 | HLA–DR4–positive AIH (n = 78) | HLA-DR4-negative AIH (n = 54) | P–value |
Discrete traits | N (%) | N (%) | Â |
 Sex |  |  | 0.524 |
  Male | 8 (10.3) | 3 (5.6) | |
  Female | 70 (89.7) | 51 (94.4) | |
 Pattern of disease onset Acute onset | 27 (34.6) | 20 (37.0) | 0.854 |
 Other autoimmune diseases | 16 (20.5) | 7 (13.0) | 0.352 |
 Death from liver disease–related causes | 3 (3.8) | 5 (9.3) | 0.271 |
 ANA positivity | 71 (91.0) | 44 (81.5) | 0.121 |
 ANA (<40/40/80/>80) | 7/9/18/44 | 10/8/10/26 | 0.435 |
 AMA positivity | 9 (11.5) | 4 (7.4) | 0.558 |
 Splenomegaly | 21 (27.6) | 23 (44.2) | 0.090 |
 Fibrosis stage (F0–F2/F3–F4) | 38/31 | 31/16 | 0.255 |
Continuous traits | Median (Min–Max) | Median (Min–Max) | P–value |
 Age (years) | 56 (15–86) | 65 (9–88) | 0.034 |
 Total bilirubin (mg/dl) | 1.1 (0.4–20.4) | 1.1 (0.5–33.2) | 0.957 |
 Aspartate aminotransferase (U/L) | 203.5 (21–2738) | 254.5 (20–1536) | 0.930 |
 Alanine aminotransferase (U/L) | 270 (15–2325) | 284 (16–2016) | 0.779 |
 Alkaline phosphatase (U/L) | 448.5 (213–1145) | 459 (131–1463) | 0.860 |
 Gamma–glutamyl transpeptidase (IU/L) | 145.5(26–1404) | 147.5 (20–679) | 0.842 |
 Prothrombin time (%) | 86 (29–130) | 82 (3–130) | 0.251 |
 Albumin (g/dL) | 3.7 (1.9–4.7) | 3.8 (2.2–4.7) | 0.239 |
 Platelets (x 104/nL) | 17.7 (8.9–39.6) | 17.55 (6.8–31.5) | 0.185 |
 Immunoglobulin G (mg/dL) | 2582.5 (938–6750) | 2074.5 (945–4961) | <0.001 |
 Immunoglobulin M (mg/dL) | 181 (62–1720) | 115 (47–888) | 0.007 |
 AIH score (except for histology score) | 14 (6–18) | 13 (7–17) | 0.117 |
 AIH score (including histology score) | 18 (9–22) | 17 (8–22) | 0.450 |