From: Evaluation of the role of HLA-DR antigens in Japanese type 1 autoimmune hepatitis
 | HLA-DR4-positive AlH (n = 22) | HLA-DR4-negative AIH (n = 27) | P-value |
Discrete traits | N (%) | N (%) | Â |
 Sex |  |  | 0.084 |
  Male | 3 (13.6) | 0 (0) | |
  Female | 19 (86.4) | 27 (100) | |
 Pattern of disease onset Acute onset | 4 (18.2) | 11 (40.7) | 0.123 |
 Other autoimmune diseases | 4 (18.2) | 2 (7.4) | 0.388 |
 Death from liver disease-related causes | 2 (9.10 | 3 (11.1) | 1.000 |
 ANA positivity | 22 (100) | 24 (88.9) | 0.242 |
 ANA (<40/40/80/<80) | 0/1/6/15 | 3/5/6/13 | 0.065 |
 AMA positivity | 5 (22.7) | 2 (7.4) | 0.219 |
 Splenomegaly | 9 (40.9) | 8 (30.8) | 0.548 |
 Fibrosis stage (F0-F2/F3-F4) | 6/11 | 16/7 | 0.053 |
Continuous traits | Median (Min-Max) | Median (Min-Max) | P-value |
 Age (years) | 72 (65–86) | 73 (66–88) | 0.657 |
 Total bilirubin (mg/dL) | 1.1 (0.5–19.0) | 1.1 (0.5–33.2) | 0.976 |
 Aspartate aminotransferase (U/L) | 188 (58–1177) | 290 (20–641) | 0.376 |
 Alanine aminotransferase (U/L) | 191 (62–1208) | 284 (16–714) | 0.330 |
 Alkaline phosphatase (U/L) | 441.5 (239–1145) | 443 (170–793) | 0.802 |
 Gamma-glutamyl transpeptidase (IU/L) | 130.5 (47–466) | 203 (20–587) | 0.287 |
 Prothrombin time (%) | 80.5 (30–104.8) | 82 (49–114.4) | 0.481 |
 Albumin (g/dL) | 3.5 (2.2–4.5) | 3.8 (2.2–4.6) | 0.190 |
 Platelets (x 104/pL) | 14.85 (9.6–27.7) | 15.7 (8.0–28.8) | 0.920 |
 Immunoglobulin G (mg/dL) | 2724.5 (1758–5495) | 2030 (1243–3157) | <0.0001 |
 Immunoglobulin M (mg/dL) | 215 (62–1330) | 98 (47–396) | 0.003 |
 AIH score (except for histology score) | 14 (7–17) | 13 (7–16) | 0.053 |
 AIH score (including histology score) | 19 (12–22) | 17 (8–21) | 0.037 |