Immune Tolerant (n = 158) | Immune clearance (n = 133) | Low Replicative (n = 99) | HBeAg negativ hepatitis (n = 54) | p value | |
---|---|---|---|---|---|
Age | 34 (28–42) | 31 (26–39) | 42 (32/49) | 43 (37–52) | <0.001a |
Gender M/F | 92/66 | 94/39 | 58/41 | 39/15 | 0.053b |
ALT IU/L | 40.5 (24–58.5) | 175 (103–356) | 22 (14–30) | 160 (112–391) | <0.001a |
HBV DNA log IU/ml | 7.65(6.45–7.70) | 7.50 (6.65–7.69) | <2.70 (<2.70–2.73) | 5.81 (5.10–6.74) | <0.001a |
HBsAg log IU/ml | 4.43 (3.54–4.76) | 3.96 (3.55–4.52) | 3.96 (3.56–4.51) | 3.28 (2.78–3.69) | <0.001a |
HBeAg log COI | 2.97 (1.93–3.13) | 2.80 (2.12–3.08) | Negative | negative | – |
Necro-inflammation (G1:G2:G3) | 109:23:26 | 36:50:47 | 82:10:7 | 18:17:19 | <0.001a |
Fibrosis: (S1, S2, S3, S4) | 84:38:16:20 | 33:48:20:32 | 65:13:10:11 | 13:15:12:14 | <0.001a |
Liver HBsAg (0:1:2:3) | 1:29:71:57 | 3:30:44:56 | 20:38:25:16 | 2:13:22:17 | <0.001a |
Liver HBcAg (0:1:2) | 78:50:30 | 85:38:10 | 96:2:1 | 49:5:0 | <0.001a |