Hepatitis B reactivation among 1962 patients with hematological malignancy in Taiwan

BMC Gastroenterology

Table 2 Risk factors of HBV reactivation in HBsAg-positive patients with hematological malignancy

Factors	Reactivation N = 97	No Reactivation N = 189	Univariate P value	Multivariate P Value	Odds ratio(95% CI)
Hematological malignancy			0.332	NA
AML	29	46
ALL	3	10
Lymphoma	46	96
CML/MPN	1	5
CLL	2	3
Myeloma	10	21
MDS/AA	6	8
Age > 65 year			0.052	0.198
Yes	11	57
No	86	132
Gender			0.781	NA
Man	55	106
Woman	42	83
Hepatitis C			0.180	0.453
Yes	4	4
No	93	185
Liver cirrhosis			0.906	NA
Yes	4	7
No	93	182
Hepatocellular carcinoma			0.032	<0.001	0.101(0.029–0.355)
Yes	3	1
No	94	188
Diabetes mellitus			0.388	NA
Yes	10	20
No	87	169
Allogeneic transplantation			0.113	0.269
Yes	28	31
No	69	158
Antiviral prophylaxis			<0.001	<0.001	4.631(2.902–7.390)
Yes	26	145
No	71	44

AML acute myeloid leukemia, ALL acute lymphoblastic leukemia, CML/MPN chronic myeloid leukemia/myeloproliferative neoplasm, CLL chronic lymphocytic leukemia, MM myeloma, MDS/AA myelodysplastic syndrome/aplastic anemia

ISSN: 1471-230X