Fig. 2
From: Validity of biopsy-based drug effects in a diet-induced obese mouse model of biopsy-confirmed NASH
Assessment of intra- and interlobular variability Quantification of liver lipids, galectin-3 (gal-3), and type I collagen α1 chain (col1a1) as determined by morphometry of stereological sections and terminal biopsy. Varity of sections used for stereological assessment of liver lipids (a), gal-3 (c), and col1a1 (e) assessed in left lateral lobe (LLL), medial lobe (ML), and right lateral lobe (RLL) from five NASH Vehicle animals. An 1 = animal 1, An 2 = animal 2 and so forth. Quantification of terminal biopsy, mean of sections from LLL (b), ML (d), and RLL (f) from five NASH vehicle animals. Data expressed as mean ± SEM (n = 6–8). **P < 0.01 vs. Biopsy, *P < 0.05 vs. Biopsy, ##P < 0.01 vs. Medial lobe, #P < 0.05 vs. Medial lobe. One-way ANOVA with Turkey’s multiple comparison test