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Table 3 Fecal incontinence subgroup analysis for year of publication, geographic region, study design and age range

From: Long-term outcomes and quality of life of patients with Hirschsprung disease: a systematic review and meta-analysis

Long-term outcome

Subgroup characteristics

Subgroup categories

Number of studies

Pooled prevalence / mean (95% CI)

Heterogeneity (I2, P)

Fecal incontinence

Year of publication

<  2008

6

0.19 (0.07, 0.30)

0, 0.71

> 2008

4

0.20 (0.06, 0.33)

0, 0.42

Geographic region

Europe

5

0.16 (0.05, 0.28)

0, 0.72

Oceania

2

0.33 (0.07, 0.59)

0, 0.34

Asia

2

0.21 (0.04, 0.40)

16.5%, 0.27

North America

1

0.06 (−0.42, 0.55)

N/A

Study design

Case-control

3

0.14 (−0.03, 0.30)

0, 0.61

Cohort study

1

0.14 (− 0.06, 0.34)

N/A

Cross-sectional

6

0.24 (0.12, 0.36)

0, 0.63

Age at follow-up (years) a

≤ 19

2

0.14 (−0.03, 0.32)

0, 0.73

>  20

4

0.20 (0.08, 0.32)

0, 0.53

Age at surgery (years) b

<  0.5

1

0.03 (−0.31, 0.37)

N/A

≥ 0.5

5

0.17 (0.07, 0.28)

0, 0.83

Constipation

Year of publication

<  2008

6

0.16 (0.02, 0.31)

36.7%, 0.162

> 2008

4

0.17 (0.04, 0.31)

0, 0.43

Geographic region

Europe

5

0.13 (0.02, 0.25)

7.3%, 0.37

Oceania

2

0.42 (0.16, 0.68)

38.4%, 0.20

Asia

2

0.08 (−0.07, 0.24)

0, 0.77

North America

1

0.06 (− 0.42, 0.55)

N/A

Study design

Case-control

3

0.23 (0.06, 0.39)

0, 0.46

Cohort study

1

0.01 (−0.19, 0.21)

N/A

Cross-sectional

6

0.17 (0.02, 0.31)

23.6%, 0.257

Age at follow-up (years) a

≤ 19

2

0.09 (−0.08, 0.27)

0, 0.89

>  20

4

0.13 (0.01, 0.25)

32.5%, 0.22

Age at surgery (years) b

<  0.5

1

0.06 (−0.28, 0.40)

N/A

≥ 0.5

5

0.13 (0.03, 0.23)

6.2%, 0.37

Bladder dysfunction

Year of publication

<  2008

2

0.08 (−0.20, 0.36)

0, 0.68

> 2008

3

0.08 (−0.09, 0.26)

0, 0.95

Geographic region

Europe

2

0.06 (−0.16, 0.28)

0, 0.90

Oceania

1

0.13 (−0.22, 0.47)

N/A

Asia

1

0.12 (−0.18, 0.41)

N/A

North America

1

0.00 (−0.48, 0.48)

N/A

Study design

Case-control

1

0.08 (−0.24, 0.39)

N/A

Cohort study

0

N/A

N/A

Cross-sectional

4

0.08 (−0.09, 0.25)

23.6%, 0.257

Age at follow-up (years) a

≤ 19

1

0.00 (−0.48, 0.48)

N/A

>  20

3

0.08 (−0.09, 0.26)

0, 0.95

Age at surgery (years) b

<  0.5

2

0.06 (−0.16, 0.28)

0, 0.90

Unclear

3

0.10 (−0.11, 0.30)

0, 0.91

  1. aOnly studies with all participants older than 20 years or younger than 19 years were included
  2. bOnly studies reporting the patients’ age when they received surgery were included