Table 2 Characteristics of the included studies-Part II
Study | Case type | Sample (size (n)/Age range (years)/Male (%)) | Adjusted RR (95%CI) | Covariates adjustment | NOS score | |
|---|---|---|---|---|---|---|
Cases | Controls | |||||
Aletaha-2019 [17] | IBD | 68,535/18–64/NM | 42,371,769/18–64/NM | 3.5 (3.3–3.8) | Age, sex, region, and insurance | 7 |
Bae-2017 [14] | IBD | 40,843/All/60.2 | 122,529/All/60.2 | 3.41 (2.61–4.44) | Age, sex, and insurance | 7 |
CD | 12,646/All/69.1 | 3.74 (2.47–5.65) | ||||
UC | 28,197/All/59.2 | 3.31 (2.49–4.40) | ||||
Burisch-2019 [16] | IBD | 11,777/≥18/NM | 1 for 5 matcheda /≥18/NM | 2.11 (1.66–2.67) | Age, sex | 8 |
CD | NM/≥18/NM | 3.59 (2.32–5.54) | ||||
UC | NM/≥18/NM | 1.67 (1.21–2.30) | ||||
Cohen-2008-1 [13] | IBD | 18,603/≥18/44.3 | 66,969/≥18/44.3 | 2.72 (2.43–3.04) | Age, sex, region, and insurance | 7 |
CD | 9267/≥18/43.0 | 37,068/≥18/43.0 | 2.76 (2.40–3.18) | |||
UC | 11,220/≥18/46.0 | 44,880/≥18/46.0 | 2.76 (2.40–3.18) | |||
Cohen-2008-2 [13] | IBD | 16,139/≥18/45.5 | 64,556/≥18/45.5 | 2.05 (1.84–2.29) | Age, sex, region, and insurance | 7 |
CD | 7404/≥18/42.7 | 29,604/≥18/42.7 | 2.37 (2.02–2.77) | |||
UC | 10,104/≥18/45.7 | 40,416/≥18/45.7 | 2.16 (1.88–2.49) | |||
Halling-2017 [12] | IBD | 47,325/All/46 | 92,839/All/46 | 1.8 (1.5–2.0) | Age, sex, and region | 8 |
CD | 13,343/All/42 | 26,172/All/42 | 2.1 (1.6–2.8) | |||
UC | 31,066/All/47 | 60,951/All/47 | 1.6 (1.3–1.9) | |||
Kappelman-2011 [11] | IBD | 1242/≤20/55 | 3353/≤20/54 | 9.6 (3.9–23.8) | Age, sex, and region | 8 |
CD | 737/≤20/56 | 1997/≤20/56 | 15.7 (4.6–53.7) | |||
UC | 488/≤20/53 | 1310/≤20/52 | 3.6 (0.8–16.1) | |||
Park-2019 [15] | IBD | 35,581/≤80/61.6 | 142,324/≤80/61.6 | 4.24 (3.25–5.52) | Age, sex | 8 |
CD | 11,803/≤80/70.9 | 47,212/≤80/70.9 | 5.59 (3.32–9.41) | |||
UC | 23,737/≤80/56.9 | 94,948/≤80/56.9 | 3.90 (2.86–5.32) | |||
Puolakka-2014 [19] | RA | 7209/≥17/32 | NM/NM/NM | 0.74 (0.51–1.03) | Age, sex | 7 |
Kronzer-2019 [18] | RA | 821/≥18/27 | 2455/≥18/27 | 3.82 (1.77–8.41) | Age, sex, region, race, BMI, education, smoking, CCI | 6 |
Weng-2007 [10] | IBD | 12,601/≤89/47.5 | 50,404/≤89/47.5 | 1.9 (1.5–2.3) | Age, sex, insurance, and smoking | 9 |
CD | 4021/≤89/44.1 | 1 for 4 matched/≤89/44.1 | 2.5 (1.8–3.5) | |||
UC | 7525/≤89/49.3 | 1 for 4 matched/≤89/49.3 | 1.5 (1.2–2.0) | |||
Yang-2018 [9] | IBD | 43,281/19–75/70.1 | 1,127,261/19–75/48.4 | 1.60 (1.52–1.68) | No | 6 |
CD | 13,925/19–75/63.5 | 1.47 (1.34–1.61) | ||||
UC | 29,356/19–75/57.6 | 1.67 (1.57–1.77) | ||||