Evaluation of role of hyperbilirubinemia as a new diagnostic marker of complicated appendicitis

BMC Gastroenterology

Table 8 Comparison of sensitivity, specificity, ppv, npv of serum total bilirubin in various studies

Authors	Study type	Number of subjects	Age (years, mean, range)	Hystologically confirmed appendicitis (n)	Perforated appendix (n)	Sensitivity	Specificity	Positive likelihood ratio	Negative likelihood ratio
Present Study by Bakshi et al. 2019	Prospective non-randomized	110	23.5 years (5–62)	110	35	0.9143	0.88	7.619	0.097
Estrada et al. [7]	Retrospective non-randomized	170	33 years (5–66)	157	41	0.56	0.69	1.81	0.64
Emmanuel et al. [31]	Retrospective non-randomized	472	27 years (5–82)	386	45	0.60	0.70	1.99	0.57
Khan et al. [32]	Prospective non-randomized	122	29 years (8–73)	118	18	0.72	0.18	0.88	1.54
Sand et al. [33]	Retrospective non-randomized	538	36 years (6–91)	376	97	0.70	0.86	5.06	0.35
Käser et al. [34]	Retrospective non-randomized	1073	22 years (5–92)	725	155	0.38	0.78	1.71	0.8
Atahan et al. [35]	Retrospective non-randomized	351	31 years (18–83)	302	45	0.80	0.84	4.9	0.24
Hong et al. [36]	Retrospective non-randomized	977	31 years	732	245	0.32	0.84	2.01	0.81
McGowan et al. [37]	Retrospective non-randomized	1271	–	1053	154	0.55	0.90	5.76	0.50

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