Variable | All patients | Sampled patients*1 | Period 1 (01/2012–12/2014)*1 | Period 2 (01/2015–04/2018)*1 | p value*2 |
---|---|---|---|---|---|
Total number of patients | 666 | 280 | 126 | 155 | |
Sex | |||||
Female (n, %) | 238 (35.7%) | 97 (34.6%) | 44 (34.9%) | 53 (34.4%) | 0.93 |
Male (n, %) | 428 (64.3%) | 183 (65.4%) | 82 (65.1%) | 101 (65.6%) | 0.93 |
Age (years) | 56.7 (17–87) | 57.3 (17.8–85.8) | 56.9 (21.5–81) | 57.7 (17.8–85.8) | 0.54 |
Days in hospital | 15.5 (1–126) | 23.0 (1–126) | 24.5 (2–97) | 22.0 (1–126) | 0.11 |
90-day mortality*3 | 148 (22.2%) | 89 (31.8%) | 38 (30.2%) | 51 (33.1%) | 0.60 |
Etiology of liver cirrhosis*4 | |||||
Alcohol-related (n, %) | 336 (50.5%) | 130 (46.4%) | 56 (44.4%) | 74 (48.1%) | 0.54 |
HCV (n, %) | 92 (13.8%) | 37 (13.2%) | 20 (15.9%) | 17 (11.0%) | 0.24 |
HBV (n, %) | 29 (4.4%) | 10 (3.6%) | 4 (3.2%) | 6 (3.9%) | 0.75 |
NASH (n, %) | 45 (6.8%) | 27 (9.6%) | 11 (8.7%) | 16 (10.4%) | 0.77 |
Other (n, %) | 226 (33.9%) | 102 (36.4%) | 45 (35.7%) | 57 (37.0%) | 0.82 |
Laboratory values at admission | |||||
MELD | 17.6 (6.43–40) | 19.8 (7.9–40.0) | 19.2 (8.6–40.0) | 19.9 (7.9–40.0) | 0.41 |
INR | 1.42 (0.97–5.64) | 1.5 (1.0–5.6) | 1.5 (1.1–3.4) | 1.5 (1.0–5.6) | 0.09 |
Creatinine (µmol/l) | 109.5 (30–878) | 124.0 (32.0–878.0) | 116.0 (40.0–691.0) | 126.0 (32.0–878.0) | 0.52 |
Thrombocytes (× 103/µl) | 117 (15–813) | 113.5 (15.0–813.0) | 110.5 (15.0–490.0) | 123.0 (17.0–813.0) | 0.28 |
CRP (mg/l) | 24 (0.4–433) | 28.1 (0.9–433.0) | 26.0 (2.0–433.0) | 30.8 (0.9–266.0) | 0.78 |
Bilirubin (µmol/l) | 42 (3–786) | 54.0 (3.0–786.0) | 54.0 (4.0–786.0) | 54.0 (3.0–676.0) | 0.85 |
Sodium (mmol/l) | 134 (115–149) | 134.0 (115.0–149.0) | 134.0 (117.0–145.0) | 134.0 (115.0–149.0) | 0.95 |
Leucocytes (× 103/µl) | 7.6 (1.1–83.4) | 8.5 (1.9–83.4) | 8.6 (2.3–83.4) | 8.5 (1.9–35.5) | 0.90 |
Patients with SBP (n, %) | 262 (39.3%) | 205 (73.2%) | 91 (72.5%) | 114 (77.3%) | 0.74 |
Patients with BSI (n, %) | 49 (7.4%) | 49 (17.5%) | 28 (22.2%) | 21 (13.6%) | 0.06 |
Patients with UTI (n, %) | 153 (23.0%) | 93 (33.2%) | 37 (29.4%) | 56 (36.4%) | 0.22 |
Patients with at least one infection (n, %) | 354 (53.2%) | ||||
Patients with one of the three infection (n, %) | 256 (38.4%) | 219 (78.2%) | 100 (79.4%) | 119 (77.3%) | 0.67 |
Patients with two of the three infections (n, %) | 86 (12.9%) | 55 (19.6%) | 22 (17.5%) | 33 (21.4%) | 0.41 |
Patients with all three infections (n, %) | 12 (1.8%) | 6 (2.1%) | 4 (3.2%) | 2 (1.3%) | 0.28 |
Patients with microbiological sampling during infection (n, %) | 281 (42.2%) | ||||
Patients with at least one positive microbiological sample (n, %) | 160 (24.0%) | 159 (56.8%) | 76 (60.3%) | 83 (53.9%) | 0.28 |