| Overall | Biologic-naïve | 1 prior biologic |  ≥ 2 prior biologic |
---|---|---|---|---|
N = 225 | N = 43 | N = 92 | N = 90 | |
Proportion of days covered during 6-month follow-up | ||||
 Mean (SD) | 0.7 (0.3) | 0.7 (0.3) | 0.7 (0.3) | 0.7 (0.3) |
 Median (IQR) | 0.8 (0.5, 1.0) | 0.8 (0.5, 1.0) | 0.9 (0.5, 1.0) | 0.8 (0.5, 1.0) |
Discontinuation during 4Â months of follow-up,a n (%) | 34 (15.1) | 9 (20.9) | 15 (16.3) | 10 (11.1) |
Time to discontinuation during 4Â months of follow-up,a days | ||||
 Mean (SD) | 42.4 (15.0) | 43.3 (15.8) | 42.0 (15.2) | 42.0 (15.5) |
 Median (IQR) | 30.0 (30.0, 60.0) | 30.0 (30.0, 60.0) | 30.0 (30.0, 60.0) | 30.0 (30.0, 60.0) |
Sensitivity analysis (12 months of follow-up) | N = 91 | N = 16 | N = 31 | N = 44 |
---|---|---|---|---|
Proportion of days covered during 12-month follow-up | ||||
 Mean (SD) | 0.7 (0.3) | 0.8 (0.2) | 0.7 (0.3) | 0.6 (0.3) |
 Median (IQR) | 0.8 (0.4, 1.0) | 0.8 (0.6, 0.9) | 0.8 (0.5, 1.0) | 0.6 (0.3, 1.0) |
Discontinuation during 10Â months of follow-up,a n (%) | 36 (39.6) | 4 (25.0) | 10 (32.3) | 22 (50.0) |
Time to discontinuation during 10Â months of follow-up,a days | ||||
 Mean (SD) | 120.0 (67.8) | 177.8 (61.7) | 131.1 (72.0) | 104.4 (62.8) |
 Median (IQR) | 99.5 (63.5, 180.0) | 198.0 (135.0, 220.5) | 105.5 (90.0, 180.0) | 94.5 (60.0, 150.0) |