Table 1 Logistic regression for characteristics to develop initial lung metastasis in patients with colorectal cancer (diagnosed 2010–2016)
Subject characteristics | Patients’ No. of CRC (2010–2016) (N = 203,138) | Univariable analysis | Multivariable analysisa | ||||
|---|---|---|---|---|---|---|---|
LM | Entire cohort | % | OR [95% CI] | P value | OR [95% CI] | P value | |
Age(years) | |||||||
≤ 50 | 1587 | 31,717 | 5.0 | 1 (Reference) | 1.00 | 1 (Reference) | 1.00 |
51–60 | 2517 | 46,551 | 5.4 | 1.09 (1.02–1.16) | 0.013 | 1.11 (1.03–1.19) | 0.007 |
61–70 | 2828 | 51,891 | 5.6 | 1.09 (1.03–1.17) | 0.005 | 1.24 (1.16–1.34) | < 0.001 |
71–80 | 2088 | 40,878 | 5.1 | 1.02 (0.96–1.09) | 0.525 | 1.34 (1.24–1.45) | < 0.001 |
81–90 | 1319 | 27,329 | 4.8 | 0.96 (0.89–1.04) | 0.321 | 1.24 (1.14–1.36) | < 0.001 |
≥ 91 | 259 | 4772 | 5.4 | 1.09 (0.95–1.25) | 0.213 | 1.13 (0.96–1.32) | 0.132 |
Sex | |||||||
Female | 4855 | 97,411 | 5.0 | 1 (Reference) | 1.00 | 1 (Reference) | 1.00 |
Male | 5743 | 105,727 | 5.4 | 1.10 (1.05–1.14) | < 0.001 | 0.93 (0.84–1.03) | 0.142 |
Race | |||||||
White | 7795 | 155,877 | 5.0 | 1 (Reference) | 1.00 | 1 (Reference) | 1.00 |
Black | 1702 | 25,423 | 6.7 | 1.36 (1.29–1.44) | < 0.001 | 1.12 (1.05–1.19) | 0.001 |
Othersb | 1078 | 19,755 | 5.5 | 1.10 (1.03–1.17) | 0.006 | 1.09 (1.01–1.18) | 0.022 |
Unknown | 23 | 2083 | 1.1 | 0.21 (0.14–0.32) | < 0.001 | 0.33 (0.21–0.50) | < 0.001 |
Marital status | |||||||
Unmarriedc | 5136 | 85,861 | 6.0 | 1 (Reference) | 1.00 | 1 (Reference) | 1.00 |
Married | 4884 | 104,171 | 4.7 | 0.77 (0.74–0.80) | < 0.001 | 0.91 (0.87–0.95) | < 0.001 |
Unknown | 578 | 13,106 | 4.4 | 0.73 (0.66–0.79) | < 0.001 | 0.93 (0.84–1.03) | 0.139 |
Insurance status | |||||||
Insured | 8087 | 168,577 | 4.8 | 1 (Reference) | 1.00 | 1 (Reference) | 1.00 |
Uninsured | 589 | 6818 | 8.6 | 1.48 (1.40–1.56) | < 0.001 | 1.11 (1.05–1.18) | 0.001 |
Any Medic aid | 1922 | 27,743 | 6.9 | 1.88 (1.72–2.05) | < 0.001 | 1.35 (1.22–1.50) | < 0.001 |
Site | |||||||
Right colon | 3107 | 81,903 | 3.8 | 1 (Reference) | 1.00 | 1 (Reference) | 1.00 |
Left colon | 3568 | 67,565 | 5.3 | 1.41 (1.35–1.49) | < 0.001 | 1.23 (1.21–1.35) | < 0.001 |
Rectum | 2898 | 47,660 | 6.1 | 1.64 (1.56–1.73) | < 0.001 | 1.96 (1.84–2.08) | < 0.001 |
Unknown | 1025 | 6010 | 17.1 | 5.22 (4.83–5.63) | < 0.001 | 1.32 (1.20–1.45) | < 0.001 |
Histological grade | |||||||
Grade I | 440 | 20,942 | 2.1 | 1 (Reference) | 1.00 | 1 (Reference) | 1.00 |
Grade II | 4796 | 119,971 | 4.0 | 1.94 (1.76–2.14) | < 0.001 | 1.35 (1.21–1.50) | < 0.001 |
Grade III | 1377 | 26,680 | 5.2 | 2.54 (2.27–2.83) | < 0.001 | 1.25 (1.10–1.40) | < 0.001 |
Grade IV | 224 | 5430 | 4.1 | 2.01 (1.70–2.36) | < 0.001 | 1.12 (0.93–1.34) | 0.229 |
Unknown | 3761 | 30,115 | 12.5 | 6.65 (6.01–7.35) | < 0.001 | 1.87 (1.67–2.09) | < 0.001 |
Lymphatic metastasis | |||||||
N0 | 3631 | 118,929 | 3.1 | 1 (Reference) | 1.00 | 1 (Reference) | 1.00 |
N1 | 3435 | 49,501 | 6.9 | 2.37 (2.26–2.48) | < 0.001 | 1.74 (1.64–1.85) | < 0.001 |
N2 | 1609 | 25,083 | 6.4 | 2.18 (2.05–2.31) | < 0.001 | 1.61 (1.49–1.74) | < 0.001 |
Unknown | 1923 | 9625 | 20.0 | 7.93 (7.47–8.42) | < 0.001 | 1.58 (1.47–1.70) | < 0.001 |
T stage | |||||||
T1 | 1121 | 37,387 | 3.0 | 1 (Reference) | 1.00 | 1 (Reference) | 1.00 |
T2 | 175 | 22,697 | 0.8 | 0.25 (0.21–0.30) | < 0.001 | 0.36 (0.30–0.42) | < 0.001 |
T3 | 2627 | 84,747 | 3.1 | 1.04 (0.96–1.11) | 0.343 | 0.74 (0.68–0.80) | < 0.001 |
T4 | 2218 | 30,766 | 7.2 | 2.51 (2.34–2.71) | < 0.001 | 1.16 (1.07–1.27) | 0.001 |
Unknown | 4457 | 27,541 | 16.2 | 6.25 (5.84–6.68) | < 0.001 | 1.80 (1.66–1.94) | < 0.001 |
CEA | |||||||
Negative | 899 | 57,688 | 1.6 | 1 (Reference) | 1.00 | 1 (Reference) | 1.00 |
Positive | 6325 | 53,812 | 11.8 | 8.41 (7.84–9.03) | < 0.001 | 2.40 (2.22–2.59) | < 0.001 |
Unknown | 3374 | 91,638 | 3.7 | 2.42 (2.24–2.60) | < 0.001 | 1.39 (1.28–1.51) | < 0.001 |
Liver metastasis | |||||||
No | 2863 | 172,420 | 1.7 | 1 (Reference) | 1.00 | 1 (Reference) | 1.00 |
Yes | 7608 | 30,258 | 25.1 | 19.89 (19.02–20.81) | < 0.001 | 9.13 (8.66–9.62) | < 0.001 |
Unknown | 127 | 460 | 27.6 | 22.59 (18.35–27.8) | < 0.001 | 4.95 (3.83–6.40) | < 0.001 |
Bone metastasis | |||||||
No | 9158 | 199,953 | 4.6 | 1 (Reference) | 1.00 | 1 (Reference) | 1.00 |
Yes | 1089 | 2454 | 44.4 | 16.62 (15.31–18.05) | < 0.001 | 3.53 (3.21–3.88) | < 0.001 |
Unknown | 351 | 731 | 48.0 | 19.24 (16.62–22.28) | < 0.001 | 2.32 (1.80–2.99) | < 0.001 |
Brain metastasis | |||||||
No | 9899 | 201,765 | 4.9 | 1 (Reference) | 1.00 | 1 (Reference) | 1.00 |
Yes | 299 | 566 | 52.8 | 21.71 (18.38–25.63) | < 0.001 | 8.53 (6.94–10.48) | < 0.001 |
Unknown | 400 | 807 | 49.6 | 19.05 (16.57–21.90) | < 0.001 | 2.45 (1.94–3.10) | < 0.001 |