A cross-sectional study describing peripheral neuropathy in patients with symptoms of gastroparesis: associations with etiology, gastrointestinal symptoms, and gastric emptying

Table 1 Clinical characteristics of patients with symptoms of gastroparesis

	All^a			Idiopathic			Diabetic			Postsurgical
	(n = 250)			(n = 148)			(n = 61)			(n = 32)
	PN	nPN	p value	PN	nPN	p value	PN	nPN	p value	PN	nPN	p value
	n = 70	n = 180	p value	n = 22	n = 126	p value	n = 33	n = 28	p value	n = 11	n = 21	p value
Prevalence within specific etiological group	28%	72%	< 0.005*	15%	85%	< 0.005*	54%	46%	< 0.005*	34%	66%	0.390
Age (years)	46 ± 16	42 ± 17	0.048*	38 ± 17	40 ± 17	0.814	48 ± 13	40 ± 15	0.056	55 ± 14	53 ± 14	0.736
Duration of Gastroparesis (years)	10 ± 15	6 ± 9	0.238	10 ± 11	6 ± 10	0.585	7 ± 11	6 ± 9	0.726	6 ± 9	10 ± 12	0.575
n females (%)	51 (73%)	144 (80%)	0.221	18 (82%)	110 (87%)	0.561	22 (67%)	19 (68%)	0.921	8 (73%)	13 (62%)	0.54
BMI (kg/m²)	29 ± 8	26 ± 7	0.009*	27 ± 7	25 ± 7	0.291	31 ± 8	29 ± 6	0.278	27 ± 12	25 ± 5	0.796
n who report neuromodulator use (%)	7 (10%)	6 (3%)	0.033*	2 (9%)	5 (4%)	0.296	4 (12%)	1 (4%)	0.225	1 (9%)	0 (0%)	0.160

n who underwent GES	All PN n = 46	All nPN n = 120	p value	Idiopathic PN n = 16	Idiopathic nPN n = 83	p value	Diabetic PN n = 22	Diabetic nPN n = 20	p value	Postsurgical PN n = 6	Postsurgical nPN n = 15	p value
n with delayed GE^b (%)	27 (59%)	58 (48%)	0.232	7 (44%)	36 (43%)	0.978	14 (64%)	8 (40%)	0.125	4 (67%)	12 (80%)	0.517
n delayed 2 h GE (%)	11 (24%)	37 (31%)	0.379	4 (25%)	22 (27%)	0.900	6 (27%)	4 (20%)	0.580	0 (0%)	9 (60%)	0.026*
GES retention at 2 h	48 ± 19	50 ± 21	0.366	48 ± 15	51 ± 17	0.373	47 ± 23	39 ± 26	0.217	45 ± 12	62 ± 25	0.102
n delayed 4 h GE (%)	26 (57%)	54 (45%)	0.200	6 (38%)	33 (40%)	0.881	14 (64%)	9 (45%)	0.004*	4 (67%)	12 (80%)	0.371
GES retention at 4 h	17 ± 19	18 ± 21	0.471	13 ± 13	14 ± 16	0.937	19 ± 23	18 ± 24	0.325	18 ± 12	37 ± 29	0.102

Correlation values	Pearson's (All Patients)		Pearson's (Idiopathic)		Pearson's (Diabetic)		Pearson's (Postsurgical)
Correlation between GES & PN at 4 h	0.02	0.801	− 0.03	0.768	0.281	0.072	0.372	0.096
Correlation between GES & PN at 4 h	0.06	0.445	− 0.071	0.489	0.248	0.112	− 0.233	0.310

^a"All patients" include 9 diabetic and postsurgical patients whose group was too small for independent statistical analysis
^b"Delayed GE" defined as being delayed at either 2 h (> 60%) or 4 h (> 10%)

ISSN: 1471-230X