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Table 2 The univariable logistic regression analysis for analyzing the risk factors for early death of advanced HCC

From: Risk factors and predictive nomograms for early death of patients with advanced hepatocellular carcinoma: a large retrospective study based on the SEER database

Characteristics

AJCC stage IVA

AJCC stage IVB

OR

95% CI

P-value

OR

95% CI

P-value

Age (%)

 <  = 40

Ref

  

Ref

  

41–60

4.620

1.757–15.876

0.005

1.957

1.330–2.888

 < 0.001

61–80

5.134

1.960–17.602

0.003

1.912

1.302–2.815

 < 0.001

 > 80

5.739

2.021–20.714

0.003

2.101

1.377–3.216

 < 0.001

Gender (%)

Female

Ref

  

Ref

  

Male

1.125

0.857–1.481

0.398

0.953

0.824–1.101

0.514

Race (%)

White

Ref

  

Ref

  

Black

0.967

0.722–1.294

0.824

1.136

0.971–1.331

0.112

Others*

0.845

0.609–1.169

0.313

1.132

0.966–1.328

0.128

Marital status (%)

Unmarried

Ref

  

Ref

  

Married

0.842

0.648–1.096

0.200

0.839

0.730–0.964

0.013

Divorced or Separated

1.108

0.785–1.566

0.559

0.954

0.793–1.150

0.623

Widowed

1.026

0.660–1.593

0.908

1.043

0.839–1.301

0.706

Unknown

0.815

0.480–1.367

0.441

0.980

0.745–1.294

0.883

Tumor size (%)

 <  = 20 mm

Ref

  

Ref

  

21–50 mm

1.530

0.759–3.357

0.257

0.822

0.593–1.135

0.236

51–100 mm

2.995

1.520–6.462

0.003

1.035

0.756–1.409

0.830

 > 100 mm

4.964

2.469–10.883

 < 0.001

1.254

0.911–1.719

0.162

Unknown

6.394

3.146–14.148

 < 0.001

1.664

1.213–2.273

0.001

Histological grade (%)

Grade I–II

Ref

  

Ref

  

Grade III–IV

1.624

1.100–2.404

0.015

2.226

1.804–2.753

 < 0.001

Unknown

1.179

0.902–1.546

0.231

1.761

1.519–2.042

 < 0.001

AFP (%)

Negative

Ref

  

Ref

  

Positive

2.075

1.489–2.923

 < 0.001

1.555

1.309–1.847

 < 0.001

Unknown

2.128

1.414–3.224

 < 0.001

1.518

1.248–1.848

 < 0.001

Fibrosis scores (%)

Ishak 0–4

Ref

  

Ref

  

Ishak 5–6

2.217

1.196–4.311

0.014

1.644

1.198–2.259

0.002

Unknown

2.356

1.320–4.435

0.005

2.001

1.498–2.676

 < 0.001

T stage (%)

T1–2

Ref

  

Ref

  

T3–4

2.431

1.920–3.087

 < 0.001

1.325

1.165–1.506

 < 0.001

TX

3.364

2.224–5.129

 < 0.001

1.591

1.358–1.865

 < 0.001

N stage (%)

N0

NA

NA

NA

Ref

  

N1

NA

NA

NA

1.185

1.033–1.360

0.016

NX

NA

NA

NA

1.338

1.146–1.565

 < 0.001

Bone metastasis (%)

No

NA

NA

NA

Ref

  

Yes

NA

NA

NA

0.729

0.644–0.825

 < 0.001

Unknown

NA

NA

NA

1.042

0.794–1.375

0.771

Brain metastasis (%)

No

NA

NA

NA

Ref

  

Yes

NA

NA

NA

0.988

0.676–1.459

0.950

Unknown

NA

NA

NA

1.172

0.918–1.507

0.208

Lung metastasis (%)

No

NA

NA

NA

Ref

  

Yes

NA

NA

NA

2.287

2.025–2.584

 < 0.001

Unknown

NA

NA

NA

1.380

1.063–1.800

0.017

Surgery (%)

No

Ref

  

Ref

  

Local tumor destruction

0.108

0.032–0.268

 < 0.001

0.094

0.047–0.171

 < 0.001

Wedge resection

0.105

0.017–0.360

0.002

0.231

0.105–0.471

 < 0.001

Lobectomy

0.034

0.002–0.161

 < 0.001

0.097

0.042–0.194

 < 0.001

Surgery but the specific operation unknown

NA

NA

NA

0.317

0.083–1.052

0.067

Radiotherapy (%)

No/Unknown

Ref

  

Ref

  

Yes

0.120

0.064–0.206

 < 0.001

0.283

0.242–0.330

 < 0.001

Chemotherapy (%)

No/Unknown

Ref

  

Ref

  

Yes

0.180

0.142–0.227

 < 0.001

0.169

0.149–0.191

 < 0.001

  1. Others*: American Indian/AK Native, Asian/Pacific Islander
  2. AJCC American Joint Commission on Cancer, HCC hepatocellular carcinoma, CI confidence interval
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BMC Gastroenterology

ISSN: 1471-230X

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