Table 3 Pearson correlation analysis of serum liver chemistries and hepatic UPR gene expression
From: Expression of unfolded protein response genes in post-transplantation liver biopsies
Unfolded protein response pathway | Gene | Pearson r | P value |
|---|---|---|---|
Correlated with ALT | Â | Â | Â |
XBP1 pathway | FICD | 0.5545 | 0.0138 |
PERK pathway | ATF3 | 0.773 | 0.0001 |
ATF6 pathway | MIS12 | 0.5015 | 0.0287 |
| Â | DNAJB11 | 0.4854 | 0.0351 |
Correlated with AST | Â | Â | Â |
XBP1 pathway | FICD | 0.6689 | 0.0017 |
| Â | STT3A | 0.5103 | 0.0256 |
| Â | MBNL2 | 0.4659 | 0.0444 |
| Â | HSPA13 | 0.681 | 0.0013 |
| Â | SEC23B | 0.6366 | 0.0034 |
PERK pathway | WARS | 0.5072 | 0.0267 |
| Â | ATF3 | 0.6847 | 0.0012 |
| Â | PPP1R15A | 0.5843 | 0.0086 |
ATF6 pathway | HYOU1 | 0.5871 | 0.0082 |
| Â | MANF | 0.6064 | 0.0059 |
| Â | HSPA5 | 0.5272 | 0.0204 |
| Â | PDIA6 | 0.5355 | 0.0181 |
| Â | DNAJB11 | 0.6268 | 0.0041 |
Correlated with total bilirubin | Â | Â | Â |
PERK pathway | PPP1R15A | 0.6351 | 0.0035 |
| Â | PON2 | 0.5278 | 0.0202 |
| Â | ATF6 | 0.6891 | 0.0011 |
ATF6 pathway | HYOU1 | 0.5111 | 0.0253 |
| Â | MANF | 0.516 | 0.0237 |
| Â | HSPA5 | 0.5366 | 0.0178 |
| Â | HERPUD1 | 0.4576 | 0.0488 |
| Â | SEL1L | 0.5285 | 0.02 |
| Â | DNAJB11 | 0.6193 | 0.0047 |