Table 6 Frequency and association between RAS status and clinicopathological features in North Africa

El-Serafi et al. [12]

(n = 90)

KRAS = 41.1%

(cod 12 + 13)

NS

N/A

N/A

N/A

N/A

Bennani et al. [13]

(n = 62)

KRAS = 29% (cod 12 + 13)

NS

NS

NS

N/A

N/A

Karim et al. [14]

(n = 48)

KRAS = 45.83%

(cod 12 + 13)

N/A

N/A

N/A

N/A

N/A

Sammoud et al. [15]

(n = 52)

KRAS = 23.07%

(cod 12 + 13)

NS

Female gender

(P = 0.017)

NS

NS

N/A

Kamal et al. [16]

(n = 80)

KRAS = 28.75%

NS

NS

N/A

N/A

N/A

Aissi et al. [17]

(n = 51)

KRAS = 31.5%

(cod 12 + 13)

NS

NS

NS

N/A

N/A

Marchoudi et al. [18]

(n = 92)

KRAS = 23.91%

(cod 12 + 13)

NS

N/A

NS

N/A

NS

Ines et al. [19]

(n = 167)

KRAS = 31.13%

(cod 12 + 13)

NS

Female gender

(P = 0.008)

NS (colon vs. rectum)

NS

N/A

Jouini et al. [20]

(n = 131)

KRAS = 68.22%

NRAS = 6.97%

(RAS = 75.2%)

NS

NS

NS

NS

For mutation class (KRAS exon 2 vs. outside KRAS exon 2, p = 0.012)

Ounissi et al. [21]

(n = 96)

KRAS = 41.79% (cod 12 + 13)

NRAS = 7.3% (exons 2,3,4)

Older

patients* (p = 0.029)

NS

Left colon* (p = 0.037)

NS

Greater differentiation*

(p = 0.044)

El Agy et al. [22]

(n = 210)

KRAS = 36.7%

NRAS = 2.9%

(RAS = 39.5%)

NS

Female gender (p = 0.003)

Left colon (p = 0.009)

Classical ADC (p = 0.01)

Moderately differentiated (p = 0.04)

Abudabous et al. [23]

(n = 34)

KRAS = 38.2%

HRAS = 0%

(cod 12 + 13)

NS

NS

Left colon

(p = 0.027)

N/A

NS

El Asri et al. [24]

(n = 151)

KRAS = 34.4%

(cod 12 + 13)

NS

NS

NS (colon vs. rectum)

N/A

N/A

Salah El-Din Youssef et al. [25] (n = 45)

KRAS = 16%

N/A

N/A

N/A

N/A

N/A

Abd El Kader et al. [26]

(n = 20)

KRAS = 80%

(cod 12 + 13)

N/A

N/A

N/A

N/A

N/A