From: Transmission of oral microbiota to the biliary tract during endoscopic retrograde cholangiography
 | Total | Cholangitis | No Cholangitis | p-value |
---|---|---|---|---|
Number of patients (%) | 49 (100%) | 16 (32.7%) | 33 (67.4%) | –- |
Number of female patients | 11 (21.4%) | 4 (7.4%) | 7 (14.4%) | 0.394 |
Age (years) | 61.4 ± 11.6 | 62.3 ± 12.8 | 60.7 ± 8.4 | 0.341 |
Smoker | 18 (36.7%) | 6 (37.5%) | 12 (36.3%) | 0.519 |
EPT before inclusion | 21 (42.9%) | 9 (56.1%) | 12 (36.4%) | 0.134 |
EPT during the study period | 28 (57.1%) | 7 (43.2%) | 21 (63.6%) | 0.213 |
Diabetes mellitus | 8 (16.3%) | 3 (18.8%) | 5 (15.2%) | 0.732 |
Malignant disease | 10 (20.4%) | 4 (25%) | 6 (18.2%) | 0.659 |
Malignant disease causing bile duct stenosis | 7 (14,3%) | 2 (12.5%) | 5 (15.2%) | 0.823 |
OLT prior to study inclusion | 17 (34.7%) | 4 (25%) | 13 (39.4%) | 0.501 |
CRP (mg/dl) | 0.95 (0.4–11.3) | 6.2 (3.4–11.3) | 0.6 (0.4–1) | 0.011 |
AST (U/l) | 61 (39–102) | 68 (43.8–133.5) | 57 (37–80.5) | 0.240 |
ALT (U/l) | 51(28–111) | 65.5 (35.3–172) | 44 (22–79.5) | 0.423 |
Lactate Dehydrogenase (U/l) | 247 (128–420) | 347 (204.8–607.2) | 200 (87–377) | 0.447 |
Alkaline Phosphatase (U/l) | 226 (142–421) | 295 (218.8) | 184 (126–328) | 0.550 |
Leucocytes (g/l) | 6.7 (4.7–8.9) | 7.7 (5.3–12.9) | 5.8 (4.6–7.7) | 0.170 |
Bilirubin (mg/dl) | 1.4 (0.7–3.3) | 2.8 (1.7–5.3) | 1.02 (0.6–2.1) | 0.375 |
Total number of ERCs | 99 | 34 (100%) | 65 (100%) | Â |
Suspected bile duct stenosis | 86 | 32 (94.1%) | 54 (83.1%) | 0.122 |
Suspected bile duct stricture after OLT | 41 | 32 (94.1%) | 9 (13.8%) | 0.029 |
Malignant disease causing stenosis | 18 | 7 (20.6%) | 11 (16.9%) | 0.653 |
Suspected choledocholithiasis | 11 | 7 (20.6%) | 4 (6.2%) | 0.030 |
Stent overall | 53 | 19 (55.9%) | 34 (52.3%) | 0.735 |
plastic stent | 40 | 16 (47.1%) | 24 (36.9%) | 0.329 |
metal stent | 6 | 2 (5.9%) | 4 (6.2%) | 0.957 |
Metal stent recanalization | 7 | 2 (12.5%) | 5 (15.5%) | 0.832 |
Received antibiotic therapy Pre ERC | 40 | 21 (61.8%) | 19 (29.2%) | 0.002 |
Received antibiotic therapy post ERC | 94 | 34 (100%) | 60 (92.3%) | 0.097 |
Overlapping microbial analysis (oral cavity/biliary system) | 33 | 14 (41.2%) | 19 (29.2%) | 0.265 |
Overlapping microbial analysis (pre ERC duodenoscope/biliary system) | 12 | 4 (11.8%) | 8 (12.3%) | 0.841 |
Overlapping microbial analysis (oral cavity/pre ERC duodenoscope/biliary system) | 7 | 3(8.8%) | 4 (6.1%) | 0.688 |
Overlapping microbial analysis (biliary system/post ERC duodenoscope) | 78 | 27 (79.4%) | 51 (79.6%) | 0.431 |
Overlapping microbial analysis (oral cavity/pre ERC duodenoscope /biliary system/post ERC duodenoscope) | 3 | 1 (2.9%) | 2(3.1%) | 0.999 |