Table 1 Socio-demographics and clinical characteristics of the three unmatched cohorts: NASH, general population, T2DM
From: The burden of nonalcoholic steatohepatitis (NASH) in the United States
| Â | Unmatched Cohorts | |||
|---|---|---|---|---|
NASH N = 136 | General Population N = 96,108 | T2DM N = 8,175 | ||
N (%) | N (%) | N (%) | ||
Demographics | ||||
 Gender | Female | 84 (61.8%) | 55,361 (57.6%) | 3,821 (46.7%) |
Male | 52 (38.2%) | 40,747 (42.4%) | 4,354 (53.3%) | |
 Race/ethnicity | Non-Hispanic White | 106 (78.0%) | 61,367 (63.8%) | 5,948 (72.8%) |
Non-Hispanic Black | 1 (0.7%) | 9,139 (9.5%) | 764 (9.3%) | |
Hispanic | 13 (9.6%) | 9,999 (10.4%) | 595 (7.3%) | |
Other | 16 (11.8%) | 15,603 (16.2%) | 868 (10.6%) | |
 Age, Mean (SD), years | 49.9 (13.4) | 46.3 (17.2) | 60.1 (12.5) | |
 Education | Less than university degree | 74 (54.4%) | 51,870 (54.0%) | 4,910 (60.1%) |
University degree or higher | 62 (45.6%) | 44,072 (45.9%) | 3,262 (39.9%) | |
Decline to answer | 0 (0.0%) | 166 (0.2%) | 3 (0.0%) | |
 Income | Below region median income | 60 (44.1%) | 39,854 (41.5%) | 3,938 (48.2%) |
At or above region median income | 73 (53.7%) | 50,353 (52.4%) | 3,855 (47.2%) | |
Decline to answer | 3 (2.2%) | 5,901 (6.1%) | 382 (4.7%) | |
 Health insurance status | Insured | 120 (88.2%) | 86,933 (90.4%) | 7,771 (95.1%) |
Not insured | 16 (11.8%) | 9,175 (9.5%) | 404 (4.9%) | |
 Health insurance type | Employer-sponsored | 58 (42.6%) | 46,146 (48.0%) | 2,592 (31.7%) |
Other | 62 (45.6%) | 38,448 (40.0%) | 5,126 (62.7%) | |
Not sure/decline to answer | 16 (11.8%) | 11,514 (12.0%) | 457 (5.6%) | |
 Currently employed | 71 (52.2%) | 55,585 (57.8%) | 3,030 (37.1%) | |
Patient Characteristics | ||||
 BMI | Obese | 91 (66.9%) | 28,523 (29.7%) | 4,937 (60.4%) |
Overweight | 22 (16.2%) | 29,155 (30.3%) | 2,215 (27.1%) | |
Normal weight | 16 (11.8%) | 32,331 (33.6%) | 783 (9.6%) | |
Underweight | 2 (1.5%) | 2,546 (2.6%) | 39 (0.5%) | |
Unknown | 5 (3.7%) | 3,553 (3.7%) | 201 (2.5%) | |
 Smoking behavior | Current smoker | 20 (14.7%) | 13,615 (14.2%) | 1,185 (14.5%) |
Former smoker | 38 (27.9%) | 23,636 (24.6%) | 2,961 (36.2%) | |
Never smoker | 78 (57.3%) | 58,857 (61.2%) | 4,029 (49.3%) | |
 Current alcohol use | None | 59 (43.4%) | 32,766 (34.1%) | 3,681 (45.0%) |
Yes, less than daily | 70 (51.5%) | 58,411 (60.8%) | 4,184 (51.2%) | |
Yes, daily | 7 (5.1%) | 4,931 (5.1%) | 310 (3.8%) | |
 Current exercise behavior | No exercise: 0 days in past month | 57 (41.9%) | 33,019 (34.4%) | 4,211 (51.5%) |
Low exercise: 1–5 days in past month | 34 (25.0%) | 19,951 (20.8%) | 1,249 (15.3%) | |
Moderate exercise: 6–11 days in past month | 18 (13.2%) | 12,896 (13.4%) | 812 (9.9%) | |
High exercise: 12 + days in past month | 27 (19.8%) | 30,242 (31.5%) | 1,903 (23.3%) | |
Comorbidities | ||||
 CCIa | CCI: 0 | 48 (35.3%) | 74,352 (77.4%) | 0 (0.00%) |
CCI: 1 | 40 (29.4%) | 12,824 (13.3%) | 5,044 (61.7%) | |
CCI: 2 | 18 (13.2%) | 5,271 (5.5%) | 1,511 (18.5%) | |
CCI: 3 +  | 30 (22.1%) | 3,661 (3.8%) | 1,620 (19.8%) | |
 Adjusted CCIa | CCI: 0 | 73 (53.7%) | 80,899 (84.2%) | 5,356 (65.5%) |
CCI: 1 | 27 (19.9%) | 8,519 (8.9%) | 1,451 (17.7%) | |
CCI: 2 | 15 (11.0%) | 4,386 (4.6%) | 814 (10.0%) | |
CCI: 3 +  | 21 (15.4%) | 2,304 (2.3%) | 554 (6.8%) | |
Physician diagnosis of: | ||||
 Hypertension | 68 (50.0%) | 23,902 (24.9%) | 5,560 (68.0%) | |
 One or more heart or blood conditionsb | 92 (67.6%) | 33,531 (34.9%) | 6,656 (81.4%) | |
 Physician diagnosis of T2DM | 45 (33.1%) | 8,175 (8.5%) | 8,175 (100.0%) | |
 One or more T2DM-related complicationc | 20 (14.7%) | 2,392 (2.5%) | 2,392 (29.3%) | |
Treatment for T2DM: | ||||
 All prescription treatments | 35 (25.7%) | 6,889 (7.2%) | 6,889 (84.3%) | |
 Insulin prescription | 14 (10.3%) | 2,034 (2.1%) | 2,034 (24.9%) | |
 Non-insulin prescription | 31 (22.8%) | 6,218 (6.5%) | 6,218 (76.1%) | |