Table 2 Quality assessment of included studies using ROBINS-I
Reference | Outcomes | Bias due to confounding | Bias in selection of participants into the study | Bias in classification of Interventions | Bias due to deviations from intended interventions | Bias due to missing data | Bias in measurement of outcomes | Bias in selection of the reported results | Overall risk of bias |
|---|---|---|---|---|---|---|---|---|---|
Mason et al. [32] | 5-year OS | Moderate | Moderate | Low | Serious | Moderate | Low | No information | Serious |
R0 resection | Moderate | Moderate | Low | Serious | Moderate | Moderate | No information | Serious | |
Sutton et al. [43] | 1-year OS | Moderate | Moderate | Low | Low | Moderate | Low | No information | Moderate |
3-year OS | Moderate | Moderate | Low | Low | Moderate | Low | No information | Moderate | |
5-year OS | Moderate | Moderate | Low | Low | Moderate | Low | No information | Moderate | |
1-year RFS | Moderate | Moderate | Low | Low | Moderate | Low | No information | Moderate | |
3-year RFS | Moderate | Moderate | Low | Low | Moderate | Low | No information | Moderate | |
Le Roy et al. [44] | 1-year OS | Moderate | Low | Low | Low | Low | Low | No information | Moderate |
3-year OS | Moderate | Low | Low | Low | Low | Low | No information | Moderate | |
5-year OS | Moderate | Low | Low | Low | Low | Low | No information | Moderate | |
R0 resection | Moderate | Low | Low | Low | Low | Moderate | No information | Moderate | |
1-year RFS | Moderate | Low | Low | Low | Low | Low | No information | Moderate | |
3-year RFS | Moderate | Low | Low | Low | Low | Low | No information | Moderate | |
5-year RFS | Moderate | Low | Low | Low | Low | Low | No information | Moderate | |
Postoperative complications | Moderate | Low | Low | Low | Low | Low | No information | Moderate | |
Ninety-day postoperative mortality | Moderate | Low | Low | Low | Low | Low | No information | Moderate | |
Riby et al. [45] | 1-year OS | Moderate | Low | Low | Low | Low | Low | No information | Moderate |
3-year OS | Moderate | Low | Low | Low | Low | Low | No information | Moderate | |
5-year OS | Moderate | Low | Low | Low | Low | Low | No information | Moderate | |
R0 resection | Moderate | Low | Low | Low | Low | Moderate | No information | Moderate | |
1-year RFS | Moderate | Low | Low | Low | Low | Low | No information | Moderate | |
3-year RFS | Moderate | Low | Low | Low | Low | Low | No information | Moderate | |
5-year RFS | Moderate | Low | Low | Low | Low | Low | No information | Moderate | |
Postoperative complications | Moderate | Low | Low | Low | Low | Low | No information | Moderate | |
Ninety-day postoperative mortality | Moderate | Low | Low | Low | Low | Low | No information | Moderate | |
Buettner et al. [46] | 1-year OS | Serious | Moderate | Low | Low | Moderate | Low | No information | Serious |
3-year OS | Serious | Moderate | Low | Low | Moderate | Low | No information | Serious | |
5-year OS | Serious | Moderate | Low | Low | Moderate | Low | No information | Serious | |
R0 resection | Serious | Moderate | Low | Low | Moderate | Moderate | No information | Serious | |
1-year RFS | Serious | Moderate | Low | Low | Moderate | Low | No information | Serious | |
3-year RFS | Serious | Moderate | Low | Low | Moderate | Low | No information | Serious | |
5-year RFS | Serious | Moderate | Low | Low | Moderate | Low | No information | Serious | |
Postoperative complications | Serious | Moderate | Low | Low | Moderate | Low | No information | Serious | |
Ninety-day postoperative mortality | Serious | Moderate | Low | Low | Moderate | Low | No information | Serious |