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Table 5 Results of publications of partial evaluations for liver metastases from colorectal cancer (lmCRC)

From: Economic evaluations of radioembolization with yttrium-90 microspheres in liver metastases of colorectal cancer: a systematic review

Author, year publication (year cost)

Stage

Comparators

Costs

Health outcomes

Original cost

Adjusted to $US PPP

Fusco, 2017 [28]

(2016)

lmCRC

(First line treatment)a

Y-90 TARE + FOLFOX

£ 209.44b

221.83 $US PPP

Δ QoL utilities (EQ-5D-3 L):

-0.001 at 2 months (CI 95%: -0.05, 0.05), -0.03 at 12 months (-0.16, 0.09),

0.03 at 24 months, (-0.09, 0.16), and

-0.03 at 36 months (-0.20, 0.14).

FOLFOX

£ 158.85b

168.25 $US PPP

 

Δ Cost at first year: £ 51.79c

Δ Cost by 3 years: £ 56,38c

54,85 $US PPP

59,72 $US PPP

Dhir, 2018 [29]

(2018)c

lmCRC

(Second line treatment)d

Y-90 TARE + MDR

$ 39,092 (n = 13; 2 days)

41,238 $US PPP

Median OS (since lmCRC diagnosis)

Y-90 TARE: 16.3 months (12.2–22.4)

HAI: 31.2 months (20.8–35.5)

HAI + MDR

$ 29,479 (n = 21; 9 days)

31,097 $US PPP

 

Δ Cost (median): $15,948

16,824 $US PPP

  1. HAI: hepatic artery infusion with floxuridine, FOLFOX: folinic acid, fluorouracil and oxaliplatin, lmCRC: liver metastases from colorectal cancer, OS: overall survival, QoL: quality of life, MDR: multi-drug regimens including oxaliplatin and/or irinotecan ± biological treatments, Y-90 TARE: transarterial radioembolization with yttrium 90, $US PPP: Purchasing-power-parity exchange rates for the year 2020
  2. a. Chemotherapy-naïve metastatic colorectal cancer patients with liver metastases. b. Only Primary care resource was considered. c. Cost year not specified, estimated from the proposed cost reference sources. d. Pre-treated patients with a heavy liver tumour burden (median of 10 lesions and almost 40% of liver parenchymal replacement by tumour)