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Table 3 Univariate and multivariate logistic regression analyses for predicting PNI probability of patients with pancreatic head adenocarcinoma in the training cohort

From: Nomogram predicts risk of perineural invasion based on serum biomarkers for pancreatic cancer

Characteristics

Univariate analysis

Multivariate analysis

B

HR (95% CI)

P value

B

HR (95% CI)

P value

Age, > 60 vs. ≤ 60, years

0.143

1.154 (0.700-1.902)

0.574

   

Gender, female vs. male

-0.379

0.685 (0.409–1.147)

0.150

   

BMI, per kg/m2

0.011

1.011 (0.928-1.100)

0.808

   

ASA grade, III vs. ≤ II

0.101

1.107 (0.542–2.261)

0.781

   

Biliary infection, yes vs. no

0.051

1.052 (0.257–4.305)

0.944

   

Obstructive jaundice, yes vs. no

0.988

2.687 (1.598–4.518)

< 0.001

   

Weight-loss ≥ 5 kg, yes vs. no

-0.189

0.828 (0.394–1.739)

0.618

   

Preoperative Hb, per g/L

-0.015

0.985 (0.968–1.002)

0.084

   

Preoperative BG per mmol/L

0.457

1.579 (1.283–1.943)

< 0.001

0.336

1.399 (1.144–1.710)

0.001

Preoperative ALB, per g/L

-0.073

0.930 (0.869–0.995)

0.034

0.010

1.010 (0.932–1.095)

0.808

Preoperative TBIL per µmol/L

0.007

1.007 (1.004–1.010)

< 0.001

0.004

1.004 (1.000-1.007)

0.029

Preoperative CA19-9, per U/mL

0.002

1.002 (1.001–1.004)

< 0.001

0.002

1.002 (1.000-1.003)

0.010

Preoperative CEA, per ng/mL

0.017

1.018 (0.962–1.076)

0.541

   

Preoperative CA125, per U/mL

0.025

1.025 (1.001–1.050)

0.040

0.010

1.010 (0.988–1.031)

0.381

Preoperative FIB, per g/L

0.472

1.603 (1.245–2.064)

< 0.001

0.093

1.097 (0.795–1.514)

0.573

Maximum tumor size, per cm †

-0.080

0.923 (0.764–1.115)

0.407

   
  1. Bold text hinted that these variables were statistically significant in univariate or multivariate analysis. ¶ Considering the collinearity between the obstructive jaundice and TBIL, only the TBIL was included in the multivariate analysis. †, preoperative imaging results
  2. Abbreviations: HR, hazard Ratio. B, coefficient; CI, confidence interval; BMI, body Mass Index; ASA grade, American Society of Anesthesiologists physical status classification; Hb, hemoglobin; BG, blood glucose; ALB, albumin; TBIL, total bilirubin; CA19-9, carbohydrate antigen19-9; CEA, carcinoembryonic antigen; CA125, carbohydrate antigen125; FIB, fibrinogen