Parameters | HR (95% CI) | p value |
---|---|---|
Univariate analysis | ||
Age | 1.052 (1.017–1.088) | 0.003 |
Sex (Male) | 1.772 (0.812–3.867) | 0.151 |
Location (Lower) | 1.067 (0.556–2.044) | 0.846 |
Surgery (TG) | 1.196 (0.612–2.338) | 0.601 |
Lymph node dissection (D2) | 1.294 (0.683–2.454) | 0.429 |
Synchronous multiple GCs (Yes) | 1.025 (0.364–2.890) | 0.963 |
Macroscopic type (3 + 4) | 3.577 (1.883–6.796) | < 0.001 |
Depth of tumor invasion | 2.827 (2.032–3.933) | < 0.001 |
Histology (por sig nec) | 2.134 (1.076–4.229) | 0.030 |
Cancer stromal volume (sci) | 2.293 (1.203–4.371) | 0.012 |
Tumor infiltration pattern (INFc) | 1.731 (0.913–3.282) | 0.093 |
*Scirrhous pattern | 3.928 (2.077–7.428) | < 0.001 |
VI grade | 2.967 (2.161–4.072) | < 0.001 |
Lymphatic invasion (Yes) | 13.902 (4.270–45.262) | < 0.001 |
Nodal metastasis | 2.404 (1.841–3.139) | < 0.001 |
Resection margin status (R1 + R2) | 4.619 (1.919–11.120) | 0.001 |
pTNM stage | 4.152 (2.633–6.547) | < 0.001 |
Neoadjuvant chemotherapy (Yes) | 2.295 (0.314–16.795) | 0.413 |
Adjuvant chemotherapy (Yes) | 4.651 (2.208–9.796) | < 0.001 |
Multivariate analysis | ||
Age | 1.035 (0.998–1.073) | 0.065 |
Scirrhous pattern | 1.507 (0.729–3.115) | 0.269 |
VI grade | 2.119 (1.439–3.120) | < 0.001 |
Resection margin status | 0.802 (0.315–2.040) | 0.643 |
pTNM stage | 2.577 (1.496–4.437) | 0.001 |