Parameters | Hematogenous recurrence (n = 17) | Nodal recurrence (n = 11) | Peritoneal recurrence (n = 14) | |||
---|---|---|---|---|---|---|
HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | |
Univariate analysis | ||||||
Age | 1.044 (0.994–1.096) | 0.008 | 1.116 (1.034–1.203) | 0.005 | 1.071 (1.009–1.136) | 0.024 |
Sex (Male) | 1.510 (0.492–4.633) | 0.472 | 0.591 (0.180–1.938) | 0.385 | 1.221 (0.383–3.897) | 0.736 |
Location (Lower) | 3.210 (0.922–11.173) | 0.067 | 1.830 (0.485–6.901) | 0.372 | 0.942 (0.327–2.715) | 0.911 |
Surgery (TG) | 0.310 (0.071–1.356) | 0.120 | 0.890 (0.236–3.355) | 0.863 | 1.276 (0.427–3.810) | 0.663 |
Lymph node dissection (D2) | 1.463 (0.557–3.845) | 0.440 | 1.265 (0.386–4.146) | 0.698 | 1.075 (0.376–3.070) | 0.893 |
Synchronous multiple GCs (Yes) | 1.188 (0.271–5.195) | 0.819 | 0.841 (0.107–6.578) | 0.869 | 0.646 (0.084–4.945) | 0.674 |
Macroscopic type (3 + 4) | 2.343 (0.865–6.347) | 0.094 | 2.707 (0.790–9.277) | 0.113 | 6.333 (2.184–18.363) | 0.001 |
Depth of tumor invasion | 2.232 (1.436–3.470) | < 0.001 | 6.074 (2.348–15.711) | < 0.001 | 3.985 (2.071–7.668) | < 0.001 |
Histology (por sig nec) | 1.126 (0.778–1.628) | 0.529 | 1.418 (0.851–2.364) | 0.180 | 1.608 (0.981–2.636) | 0.060 |
Cancer stromal volume (sci) | 0.978 (0.340–2.817) | 0.968 | 2.714 (0.827–8.903) | 0.100 | 8.086 (2.254–29.011) | 0.001 |
Tumor infiltration pattern (INFc) | 0.753 (0.278–2.035) | 0.575 | 3.838 (1.017–14.479) | 0.047 | 8.689 (1.942–38.882) | 0.005 |
VI grade | 3.845 (2.331–6.343) | < 0.001 | 2.513 (1.402–4.505) | 0.002 | 3.157 (1.846–5.397) | < 0.001 |
Lymphatic invasion (Yes) | 18.491 (2.448–139.653) | 0.005 | 88.559 (0.639–12265.7) | 0.075 | 7.574 (1.691–33.931) | 0.008 |
Nodal metastasis | 2.407 (1.608–3.602) | < 0.001 | 4.057 (2.062–7.983) | < 0.001 | 2.444 (1.585–3.771) | < 0.001 |
Resection margin status (R1 + R2) | 6.932 (2.252–21.332) | 0.001 | 11.132 (2.899–42.745) | < 0.001 | 4.899 (1.072–22.396) | 0.040 |
pTNM stage | 3.638 (1.898–6.974) | < 0.001 | 16.017 (2.661–96.403) | 0.002 | 7.631 (2.759–21.107) | < 0.001 |
Neoadjuvant chemotherapy (Yes) | 4.697 (0.621–35.531) | 0.134 | 0.049 (0.000- 3.3E + 09) | 0.812 | 0.049 (0.000–2.474E + 8) | 0.791 |
Adjuvant chemotherapy (Yes) | 5.844 (1.880–18.165) | 0.002 | 7.492 (1.551–36.194) | 0.012 | 3.926 (1.310–11.765) | 0.015 |
Multivariate analysis | ||||||
VI grade | 3.145 (1.809–5.470) | < 0.001 | 1.495 (0.681–3.280) | 0.316 | 2.090 (1.092–3.999) | 0.026 |
pTNM stage | 2.099 (1.023–4.309) | 0.043 | 14.189 (2.275–88.511) | 0.005 | 5.759 (1.978–16.769) | 0.001 |