The predictive value of CD4, CD8, and C—reactive protein in the prognosis of schistosomal and non-schistosomal colorectal cancer

Cheng, Meihong; Jing, Hongyan; Bu, Dacheng; Liu, Jing; Lu, Kui; Liu, Jican; Xu, Yanchao; Zhu, Ting; Hou, Yingyong; Yao, Junxia; Zhai, Qilin; Wang, Weixia

doi:10.1186/s12876-023-02834-z

Table 3 The association between clinicopathological characteristics and sTILs

From: The predictive value of CD4, CD8, and C—reactive protein in the prognosis of schistosomal and non-schistosomal colorectal cancer

Characteristic		iCD4		P	sCD4			iCD8		P	sCD8		P
Characteristic		Low (N = 110)	High (N = 241)	P	Low (N = 135)	High (N = 216)	P	Low (N = 65)	High (N = 286)	P	Low (N = 238)	High (N = 113)	P
Age(< 60ys)				0.223			0.520			< 0.001			0.500
	< 60	21	62		29	54		5	78		55	28
	≥ 60	89	179		106	162		60	208		188	85
Gender				0.198			0.574			0.095			0.813
	Male	72	140		79	133		45	167		148	68
	Female	38	101		56	83		20	119		95	45
Tumor site				0.676			0.773			0.442			0.506
	Rectum	29	65		34	60		16	78		66	30
	Left colon	33	82		45	70		18	97		75	41
	Right colon	48	94		56	86		31	111		102	42
Tumor size				0.818			0.913			0.496			0.247
	< 5 cm	56	118		67	107		29	145		115	63
	≥ 5 cm	54	123		68	108		36	141		128	50
Tumor differentiation				0.998			0.699			0.337			0.499
	Well diff	84	183		100	167		47	220		182	88
	Poor diff	25	58		35	49		18	66		61	25
LVI				0.091			0.169			0.316			0.809
	Negative	63	163		80	146		39	187		158	70
	Positive	47	78		55	70		26	99		85	43	0.550
Nervous invasion				0.693			0.706			0.998
	Negative	99	220		124	195		59	260		219	104
	Positive	11	21		11	21		6	26		24	9
Tumor deposit				0.375			0.181			0.032			0.004
	≤ 2	94	215		115	194		52	257		206	106
	> 2	16	26		20	22		13	29		37	7
Colonic perforation				0.555			0.259			0.715			0.762
	No	105	233		128	210		62	276		233	110
	Yes	5	8		7	6		3	10		10	3
Ulceration				0.163			0.739			0.998			0.816
	No	57	145		80	122		37	165		141	65
	Yes	53	96		55	94		28	121		102	48
Pathological T stage				0891			0.432			0.871			0.168
	I + II	24	56		27	53		14	66		50	32
	III	86	185		108	163		51	220		193	81
Lymph node metastasis				0.198			0.045			0.677			0.481
	No	59	148		70	137		37	170		140	68
	Yes	51	93		65	79		28	116		103	45
TNM stage				0.160			0.001			0.275			0.416
	I + II	54	138		58	134		32	160		129	65
	III + IV	56	103		77	82		33	126		114	48
Tumor budding				0.636			0.031			0.888			0.635
	< 5 cells	64	146		73	137		39	171		139	72
	≥ 5 cells	46	95		62	79		26	115		104	41
Histological type				0.591			0.863			0.831			0.146
	Adenocarcinoma	94	214		117	191		57	251		208	104
	Mucinous/SRCC	16	27		18	25		8	35		35	9
Schistosomiasis				0.639			0.144			0.998			0.813
	Negtive	65	149		75	139		40	174		147	67
	Positive	45	92		59	78		26	111		96	41

----: Data is not applicable
Abbreviations: N Number, LN Lymph node, iCD4 Intratumoral CD4, sCD4 Stromal CD4, iCD8 Intratumoral CD8, sCD8 Stromal CD8, LVI Lymph vascular invasion, The association between schistosomiasis and clinicopathological characteristics was evaluated by using the Chi square and Fisher’s exact tests

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ISSN: 1471-230X

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