Table 4 Univariate and multivariate Cox regression of clinicopathological for overall survival

P

HR(95%CI)

P

HR(95%CI)

P

HR(95%CI)

Univariate analysis

 iCD4

0.015

0.660(0.472-0.923)

0.076

0.662(0.419-1.044)

0.123

0.676(0.411-1.112)

 sCD4

0.002

0.602(0.435-0.834)

<0.001

0.452(0.292-0.701)

0.75

0.924(0.566-1.507)

 iCD8

<0.001

0.445(0.310-0.638)

0.002

0.459(0.283-0.745)

0.001

0.412(0.239-0.711)

 sCD8

0.176

0.776(0.538-1.120)

0.057

0.612(0.369-1.015)

0.04

0.538(0.297-0.972)

 Scrp

0.761

1.060(0.728-1.545)

0.478

1.231(0.685-2.210)

0.64

1.168(0.610-2.234)

 tCRP

0.263

0.754(0.460-1.236)

0.796

0.906(0.430-1.908)

0.301

0.615(0.244-1.547)

 Age (<60ys)

0.01

1.759(1.142-2.708)

0.122

1.454(0.905-2.336)

0.232

21.827(0.139-3436.270)

 Gender (male/female)

0.008

1.602(1.129-2.271)

0.017

0.562(0.350-0.901)

0.307

1.311(0.779-2.207)

 Tumor size(5cm)

0.913

1.018(0.728-1.400)

0.591

0.886(0.569-1.378)

0.32

1.282(0.786-2.089)

Tumor site

 Rectum

Refer

Refer

Refer

 Left colon

0.908

1.025(0.676-1.553)

0.672

0.889(0.515-1.534)

0.484

1.263(0.657-2.427)

 Right colon

0.464

0.859 (0.572-1.290)

0.054

0.590 (0.344-1.010)

0.13

1.631 (0.865-3.076)

Pathological T stage

<0.001

2.591(1.562-4.297)

0.001

3.363(1.620-6.980)

0.087

1.851(0.915-3.747)

Lymph node metastasis

<0.001

2.802(2.012-3.902)

<0.001

2.447(1.573-3.807)

<0.001

3.552(2.141-5.894)

TNM stage

<0.001

3.197(2.271-4.501)

<0.001

2.764(1.752-4.358)

<0.001

4.219(2.497-7.128)

Tumor differentiation

<0.001

1.889(1.334-2.674)

0.003

2.009(1.259-3.206)

0.054

1.668(0.991-2.809)

LVI

<0.001

3.251(1.987-5.318)

<0.001

2.816 (1.808-4385)

0.275

1.321 (0.801-2.180)

Nervous invasion

0.14

1.497(0.876-2.559)

0.391

1.424 (0.710-2.857)

0. 206

1.727 (0.741-4.024)

Tumor deposit

<0.001

4.006(2.686-5.973)

<0.001

3.973(2.359-6.692)

<0.001

4.138(2.205-7.769)

Colonic perforation

0.541

0.700(0.223-2.198)

0.763

1.194(0.377-3.786)

0.5

0.506(0.070-3.657)

Tummor budding

<0.001

2.028(1.400-2.938)

<0.001

2.824(1.813-4.400)

0.237

1.354(0.819-2.238)

Schistosomiasis

0.044

1.399(1.009-1.940)

—

—

—

—

Ulceration

0.624

0.9205(0.660-1.282)

0.744

1.077(0.691-1.676)

0.971

1.008(0.670-1.514)

Histological type

0.921

1.025(0.626-1.680)

0.283

1.400 (0.758-2.586)

0.467

0.760(0.362-1.594)

Multivariate analysis

 Age

—

—

—

—

0.967

1669993.854(0.000-4.660E+255)

 Gender

0.009

1.614(1.127-2.310)

0.023

1.771(1.084-2.896)

—

—

 Pathological T stage

0.035

1.756(1.041-2.962)

0.046

2.182(1.015-4.688)

—

—

 TNM stage

< 0.001

2.225(1.512-3.273)

—

—

—

—

 Lymph node metastasis

—

—

—

—

<0.001

2.715(1.570-4.696)

 Tumor differentiation

—

—

—

—

0.254

1.366(0.800-2.331)

 sCD4

0.038

0.698(0.497-0.980)

0.006

0.527(0.334-0.859)

 iCD8

0.003

0.565(0.388-0.822)

—

—

0.02

0.518(0.298-0.903)

 sCD8

—

—

—

—

0.156

0.648(0.356-1.180)

 Tumor Budding

—

—

0.034

1.675(1.039-2.700)

—

—

 Schistosomiasis

0.045

1.404(1.007-1.958)

—

—

—

—

 Lymphovascular invasion

—

—

0.061

1.590(0.978-2.586)

—

—

 Tumor deposit

<0.001

2.233(1.430-3.488)

0.002

2.488(1.413-4.380)

0.015

2.257(1.158-4. 400)