From: Serum liver fibrosis markers predict hepatic decompensation in compensated cirrhosis
Variable | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | |
Age | 1.043 (1.017–1.070) | 0.001 | 1.047 (1.011–1.084) | 0.011 |
Males | 0.574 (0.339–0.972) | 0.039 | 0.459 (0.235–0.899) | 0.023 |
Etiology of cirrhosis | Â | Â | Â | Â |
 Hepatitis B | Reference |  | Reference |  |
 Hepatitis C | 1.839 (0.864–3.912) | 0.114 | 1.185 (0.518–2.710) | 0.688 |
 Autoimmune | 2.136 (0.747–6.109) | 0.157 | 1.583 (0.483–5.186) | 0.448 |
 Alcohol | 4.679 (1.928–11.354) | 0.001 | 3.635 (1.340–9.857) | 0.011 |
 Others | 3.624 (1.753–7.494) | 0.001 | 4.832 (2.184–10.687) | < 0.001 |
Small esophageal varices | 3.879 (2.116, 7.110) | < 0.001 | 3.098 (1.609, 5.965) | 0.001 |
ALT | 0.999 (0.998–1.001) | 0.391 |  |  |
AST | 1.000 (0.999–1.001) | 0.996 |  |  |
GGT | 1.001 (1.001–1.002) | < 0.001 | 1.002 (1.001–1.003) | 0.001 |
ALB | 0.924 (0.885–0.965) | < 0.001 | 1.007 (0.954–1.063) | 0.804 |
TBIL | 1.003 (0.997–1.010) | 0.329 |  |  |
Cr | 0.986 (0.967–1.006) | 0.164 |  |  |
INR | 1.135 (0.939–1.373) | 0.190 |  |  |
PLT | 0.984 (0.978–0.990) | < 0.001 | 0.986 (0.977–0.995) | 0.002 |
MELD score | 1.101 (1.045–1.160) | < 0.001 | 1.010 (0.907–1.124) | 0.858 |
APRI | 1.039 (1.001–1.079) | 0.044 | 1.037 (0.960–1.121) | 0.353 |
FIB-4 index | 1.088 (1.048–1.131) | < 0.001 | 0.902 (0.789–1.031) | 0.130 |
HA | 1.000 (1.000-1.001) | 0.560 | Â | Â |
LN | 1.016 (1.011–1.021) | < 0.001 | 1.010 (1.003–1.017) | 0.007 |
CIV | 1.007 (1.005–1.009) | < 0.001 | 1.004 (1.001–1.008) | 0.022 |
PIIINP | 1.018 (0.986–1.052) | 0.275 |  |  |