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Table 5 Univariate and multivariate analysis for baseline predictors of ascites

From: Serum liver fibrosis markers predict hepatic decompensation in compensated cirrhosis

Variable

Univariate analysis

Multivariate analysis

HR (95% CI)

P value

HR (95% CI)

P value

Age

1.043 (1.017–1.070)

0.001

1.047 (1.011–1.084)

0.011

Males

0.574 (0.339–0.972)

0.039

0.459 (0.235–0.899)

0.023

Etiology of cirrhosis

    

 Hepatitis B

Reference

 

Reference

 

 Hepatitis C

1.839 (0.864–3.912)

0.114

1.185 (0.518–2.710)

0.688

 Autoimmune

2.136 (0.747–6.109)

0.157

1.583 (0.483–5.186)

0.448

 Alcohol

4.679 (1.928–11.354)

0.001

3.635 (1.340–9.857)

0.011

 Others

3.624 (1.753–7.494)

0.001

4.832 (2.184–10.687)

< 0.001

Small esophageal varices

3.879 (2.116, 7.110)

< 0.001

3.098 (1.609, 5.965)

0.001

ALT

0.999 (0.998–1.001)

0.391

  

AST

1.000 (0.999–1.001)

0.996

  

GGT

1.001 (1.001–1.002)

< 0.001

1.002 (1.001–1.003)

0.001

ALB

0.924 (0.885–0.965)

< 0.001

1.007 (0.954–1.063)

0.804

TBIL

1.003 (0.997–1.010)

0.329

  

Cr

0.986 (0.967–1.006)

0.164

  

INR

1.135 (0.939–1.373)

0.190

  

PLT

0.984 (0.978–0.990)

< 0.001

0.986 (0.977–0.995)

0.002

MELD score

1.101 (1.045–1.160)

< 0.001

1.010 (0.907–1.124)

0.858

APRI

1.039 (1.001–1.079)

0.044

1.037 (0.960–1.121)

0.353

FIB-4 index

1.088 (1.048–1.131)

< 0.001

0.902 (0.789–1.031)

0.130

HA

1.000 (1.000-1.001)

0.560

  

LN

1.016 (1.011–1.021)

< 0.001

1.010 (1.003–1.017)

0.007

CIV

1.007 (1.005–1.009)

< 0.001

1.004 (1.001–1.008)

0.022

PIIINP

1.018 (0.986–1.052)

0.275

  
  1. ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, gamma-glutamyl transpeptidase; ALB, albumin; TBIL, total bilirubin; Cr, Creatinine; INR, international normalized ratio; PLT, platelet; MELD, model for end-stage liver disease; APRI, AST-to-PLT ratio index; FIB-4, fibrosis-4 score; HA, hyaluronic acid; LN, laminin; CIV, collagen IV; PIIINP, N-terminal propeptide of type III collagen; HR, hazard ratio; CI, confidence interval