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Table 6 Univariate and multivariate analysis for baseline tertiles of serum liver fibrosis markers predicting hepatic decompensation

From: Serum liver fibrosis markers predict hepatic decompensation in compensated cirrhosis

Serum liver fibrosis markers

Unadjusted

Adjusted*

HR (95% CI)

P value

HR (95% CI)

P value

HA (ng/mL)

    

Tertile 1

Reference

 

Reference

 

Tertile 2

2.138 (0.973, 4.697)

0.058

1.779 (0.793, 3.993)

0.162

Tertile 3

3.825 (1.855, 7.891)

< 0.001

1.462 (0.682, 3.137)

0.329

LN (ng/mL)

    

Tertile 1

Reference

 

Reference

 

Tertile 2

0.838 (0.403, 1.743)

0.636

0.987 (0.466, 2.092)

0.972

Tertile 3

3.042 (1.701, 5.440)

< 0.001

1.659 (0.878, 3.136)

0.119

CIV (ng/mL)

    

Tertile 1

Reference

 

Reference

 

Tertile 2

7.367 (2.218, 24.473)

0.001

4.787 (1.419, 16.152)

0.012

Tertile 3

13.496 (4.183, 43.544)

< 0.001

5.153 (1.508, 17.604)

0.009

PIIINP (ng/mL)

    

Tertile 1

Reference

 

Reference

 

Tertile 2

2.223 (1.147, 4.310)

0.018

1.368 (0.692, 2.703)

0.367

Tertile 3

2.507 (1.302, 4.827)

0.006

1.287 (0.650, 2.548)

0.469

  1. * Adjustments for age, etiology of cirrhosis, small esophageal varices, ALB, PLT, MELD score, and FIB-4 index
  2. HA, hyaluronic acid; LN, laminin; CIV, collagen IV; PIIINP, N-terminal propeptide of type III collagen; ALB, albumin; PLT, platelet; MELD, model for end-stage liver disease; FIB-4, fibrosis-4 score; HR, hazard ratio; CI, confidence interval