Table 1 Factors associated with the occurrence of spCRC

Age

1.01 (1.01–1.01)

 < 0.001

1.01 (1.01–1.01)

 < 0.001

Sex

 Female

Ref

Ref

 Male

1.09 (1.03–1.15)

0.004

1.17 (1.10–1.24)

 < 0.001

Race

 Black

Ref

 Unknown

0.91 (0.80–1.03)

0.126

0.91 (0.80–1.03)

0.133

 White

1.02 (0.93–1.11)

0.743

0.95 (0.87–1.04)

0.257

Insurance

 Any Medicaid

Ref

Ref

 Insured

0.96 (0.86–1.07)

0.463

0.87 (0.78–0.97)

0.010

 Insured/No specifics

1.12 (0.99–1.28)

0.083

0.98 (0.86–1.12)

0.797

 Uninsured

1.10 (0.89–1.36)

0.387

1.09 (0.88–1.35)

0.453

 Blank(s)

1.53 (1.37–1.70)

 < 0.001

1.37 (1.29–1.53)

 < 0.001

Tumor site

 Left colon

Ref

Ref

 Other cancer

0.22 (0.03–1.54)

0.127

0.79 (0.11–5.66)

0.814

 Other digestive

0.30 (0.27–0.32)

 < 0.001

0.46 (0.42–0.50)

 < 0.001

 Other rectum

0.53 (0.49–0.59)

 < 0.001

0.74 0.66–0.82)

 < 0.001

 Right colon

0.78 (0.73–0.84)

 < 0.001

0.73 (0.68–0.79)

 < 0.001

Histology

 Adenocarcinoma

Ref

 Mucous adenocarcinoma

1.27 (1.14–1.42)

 < 0.001

1.19 (1.07–1.33)

0.002

 Signet ring cell carcinoma

0.55 (0.42–0.71)

 < 0.001

0.91 (0.70–1.20)

0.481

 Others

0.49 (0.45–0.52)

 < 0.001

0.85 (0.78–0.93)

 < 0.001

Grade

 Grade I/Grade II

Ref

 Grade III/Grade IV

0.76 (0.70–0.82)

 < 0.001

0.92 (0.84–0.99)

0.039

 Unknown

0.41 (0.38–0.45)

 < 0.001

0.73 (0.66–0.80)

 < 0.001

T stage

 T2

Ref

 T3

1.32 (1.23–1.41)

 < 0.001

1.61 (1.40–1.85)

 < 0.001

 T4

1.24 (1.12–1.36)

 < 0.001

1.90 (1.63–2.22)

 < 0.001

 Unknown

0.53 (0.49–0.59)

 < 0.001

1.28 (1.01–1.61)

0.040

N stage

 N0

Ref

 N1

0.75 (0.70–0.81)

 < 0.001

0.87 (0.76–0.99)

0.044

 N2

1.08 (0.98–1.19)

0.108

1.09 (0.93–1.27)

0.312

 N3

0.30 (0.14–0.64)

0.002

0.71 (0.32–1.57)

0.394

 Unknown

0.34 (0.31–0.38)

 < 0.001

0.78 (0.62–0.98)

0.036

M stage

 M0

Ref

 M1

0.40 (0.36–0.44)

 < 0.001

0.49 (0.30–0.80)

0.004

 Unknown

0.34 (0.30–0.38)

 < 0.001

0.53 (0.41–0.68)

 < 0.001

AJCC stage

 I

Ref

 II

1.12 (1.03–1.21)

0.005

0.70 (0.60–0.82)

 < 0.001

 III

1.05 (0.96–1.13)

0.279

0.69 (0.56–0.84)

0.001

 IV

0.42 (0.38–0.48)

 < 0.001

0.66 (0.41–0.08)

0.090

 Unknown

0.46 (0.41–0.51)

 < 0.001

0.83 (0.64–1.06)

0.138

Radiation

 No/Unknown

Ref

 Yes

0.68 (0.62–0.74)

 < 0.001

0.69 (0.57–0.83)

 < 0.001

Chemotherapy

 No/Unknown

Ref

 Yes

0.70 (0.66–0.74)

 < 0.001

0.93 (0.86–1.00)

0.055

Radiation sequence

 Only one

Ref

Ref

 After

0.93 (0.82–1.05)

0.252

1.52 (1.22–1.88)

0.001

 Before

0.72 (0.63–0.84)

 < 0.001

0.95 (0.76–1.20)

0.687

 Both

0.46 (0.21–1.03)

0.059

0.64 (0.28–1.46)

0.288

 Unknown

1.04 (0.39–2.78)

0.940

1.59 (0.59–4.28)

0.358