Table 3 Factors associated with the mortality of ipCRC and spCRC

Age

1.04 (1.04–1.04)

 < 0.001

1.04 (1.04–1.04)

 < 0.001

1.02 (1.01–1.02)

 < 0.001

1.02 (1.02–1.03)

 < 0.001

Gender

 Female

Ref

Ref

Ref

Ref

 Male

1.00 (0.99–1.01)

0.999

0.88 (0.87–0.89)

 < 0.001

1.05 (0.97–1.14)

0.236

1.13 (1.04–1.23)

0.003

Race

 White (ref)

Ref

Ref

Ref

Ref

 black

1.10 (1.09–1.12)

 < 0.001

1.15 (1.13–1.17)

 < 0.001

1.14 (1.01–1.29)

0.031

1.20 (1.06–1.35)

0.004

 Other

0.83 (0.81–0.84)

 < 0.001

0.86 (0.84–0.87)

 < 0.001

-

-

 Unknown

0.13 (0.11–0.15)

 < 0.001

0.18 (0.15–0.21)

 < 0.001

0.86 (0.74–0.99)

0.033

0.89 (0.77–1.02)

0.100

Insurance

 Insured

Ref

Ref

Ref

Ref

 Uninsured

1.56 (1.54–1.59)

 < 0.001

1.45 (1.42–1.47)

 < 0.001

1.02 (0.77–1.36)

 < 0.001

1.36 (1.16–1.59)

0.001

 Insured/No specifics

1.16 (1.14–1.17)

 < 0.001

1.13 (1.11–1.14)

 < 0.001

1.10 (0.96–1.27)

0.1726

0.76 (0.69–0.83)

 < 0.001

 Any Medicaid

1.30 (1.28–1.32)

 < 0.001

1.10 (1.08–1.12)

 < 0.001

1.35 (1.19–1.57)

0.001

1.09 (0.94–1.25)

0.250

 Unknown

1.28 (1.24–1.33)

 < 0.001

1.45 (1.40–1.51)

 < 0.001

0.73 (0.66–0.80)

0.730

1.22 (0.92–1.63)

0.167

Site

 Right colon

Ref

Ref

Ref

Ref

 Left colon

0.79 (0.78–0.80)

 < 0.001

0.94 (0.93–0.95)

 < 0.001

0.77 (0.67–0.89)

 < 0.001

0.87 (0.74–1.02)

0.081

 Others

2.81 (2.74–2.88)

 < 0.001

1.35 (1.31–1.38)

 < 0.001

0.89 (0.78–1.03)

0.113

1.12 (0.95–1.33)

0.184

 Rectum

0.78 (0.77–0.79)

 < 0.001

0.88 (0.86–0.89)

 < 0.001

0.93 (0.61–1.41)

0.734

1.61 (0.86–3.01)

0.134

Histology

 Adenocarcinoma

Ref

Ref

Ref

Ref

 Mucous adenocarcinoma

1.14 (1.12–1.16)

 < 0.001

1.06 (1.04–1.08)

 < 0.001

0.91 (0.79–1.06)

0.226

0.88 (0.75–1.02)

0.084

 Signet ring cell carcinoma

2.22 (2.13–2.32)

 < 0.001

1.40 (1.34–1.46)

 < 0.001

1.64 (1.20–2.24)

0.002

1.64 (1.19–2.25)

0.002

 Others

0.71 (0.70–0.72)

 < 0.001

0.85 (0.83–0.86)

 < 0.001

0.80 (0.72–0.88)

 < 0.001

0.93 (0.82–1.06)

0.259

Grade

 Grade I/Grade II

Ref

Ref

Ref

Ref

 Grade III/Grade IV

1.48 (1.45–1.51)

 < 0.001

1.15 (1.11–1.18)

 < 0.001

1.20 (1.08–1.33)

 < 0.001

0.99 (0.89–1.11)

0.947

 Unknown

2.01 (1.96–2.06)

 < 0.001

1.27 (1.22–1.30)

 < 0.001

0.95 (0.84–1.07)

0.367

1.05 (0.91–1.22)

0.507

T stage

 T1/T2

Ref

Ref

Ref

Ref

 T3

1.52 (1.50–1.55)

 < 0.001

1.17 (1.14–1.20)

 < 0.001

1.46 (1.33–1.61)

 < 0.001

1.12 (0.93–1.37)

0.224

 T4

3.25 (3.19–3.30)

 < 0.001

1.76 (1.71–1.80)

 < 0.001

2.23 (1.96–2.54)

 < 0.001

1.63 (1.32–2.01)

 < 0.001

 Unknown

0.69 (0.66–0.72)

 < 0.001

1.17 (1.14–1.20)

 < 0.001

1.25 (1.09–1.44)

0.001

1.19 (0.85–1.67)

0.030

N stage

 N0

Ref

Ref

Ref

Ref

 N1

1.52 (1.50–1.54)

 < 0.001

1.18 (1.15–1.21)

 < 0.001

1.45 (1.31–1.61)

 < 0.001

1.06 (0.85–1.32)

0.586

 N2

2.45 (2.42–2.49)

 < 0.001

1.80 (1.76–1.84)

 < 0.001

1.91 (1.70–2.15)

 < 0.001

1.36 (1.08–1.72)

0.010

 N3

-

-

-

-

1.85 (0.69–4.94)

0.219

-

-

 NX

1.81 (1.78–1.84)

 < 0.001

1.05 (1.02–1.08)

 < 0.001

1.07 (0.92–1.24)

0.382

1.86 (0.66–5.22)

0.241

M stage

 M0

Ref

Ref

Ref

Ref

 M1

5.54 (5.48–5.61)

 < 0.001

3.00 (2.61–3.45)

 < 0.001

2.44 (2.13–2.78)

 < 0.001

4.51 (2.00–10.18)

0.001

 MX

1.23 (1.21–1.26)

 < 0.001

0.76 (0.73–0.79)

 < 0.001

0.85 (0.73–0.99)

0.044

0.75 (0.52–1.08)

0.120

AJCC

 0

Ref

Ref

 I

1.20 (1.16–1.25)

 < 0.001

1.14 (1.10–1.19)

 < 0.001

Ref

-

Ref

 II

1.68 (1.62–1.75)

 < 0.001

1.24 (1.18–1.30)

 < 0.001

1.39 (1.24–1.55)

 < 0.001

1.15 (0.93–1.43)

0.188

 III

2.18 (2.09–2.27)

 < 0.001

1.55 (1.48–1.63)

 < 0.001

1.85 (1.65–2.07)

 < 0.001

1.47 (1.08–1.98)

0.013

 IV

9.31 (8.95–9.68)

 < 0.001

1.84 (1.59–2.13)

 < 0.001

3.08 (2.65–3.58)

 < 0.001

0.61 (0.27–1.36)

0.227

 Unknown stage

2.47 (2.37–2.57)

 < 0.001

1.84 (1.74–1.94)

 < 0.001

1.23 (1.06–1.43)

0.006

1.14 (0.79–1.63)

0.483

 Radiation (No/Unknown)

1.06 (1.05–1.08)

 < 0.001

1.04 (1.01–1.07)

 < 0.001

1.23 (1.10–1.38)

 < 0.001

1.82 (1.43–2.33)

 < 0.001

 Chemotherapy

0.85 (0.84–0.86)

 < 0.001

1.47 (1.45–1.49)

 < 0.001

1.29 (1.19–1.40)

 < 0.001

0.94 (0.84–1.04)

 < 0.001

Radiation sequence

 Only one

Ref

Ref

Ref

Ref

 After surgery

0.90 (0.88–0.93)

 < 0.001

1.39 (1.33–1.44)

 < 0.001

1.24 (1.06–1.46)

0.007

0.68 (0.47–0.81)

0.001

 Before surgery

0.60 (0.58–0.61)

 < 0.001

1.35 (1.31–1.40)

 < 0.001

0.95 (0.77–1.16)

0.597

0.55 (0.40–0.74)

 < 0.001

 Both

0.77 (0.56–1.08)

0.128

1.17 (0.84–1.64)

0.347

0.44 (0.11–1.76)

0.246

0.37 (0.09–1.49)

0.160

 Unknown

1.79 (1.55–2.05)

 < 0.001

1.39 (1.20–1.60)

 < 0.001

0.39 (0.06–2.78)

0.349

0.39 (0.05–2.80)

0.350