Fig. 1

 H & E-stained liver sections of the studied groups. A, a (control group): normal hepatic architecture with classic hepatic lobules formed of anastomosing cords of acidophilic hepatocytes (H), separated with blood sinusoids (BS) and some hepatocytes are binucleated (arrowheads). The portal tract (PT) is seen at the periphery of the lobule. B, b & C, c (4 & 8 wks CCl4 treated groups respectively): showing micro and macrovesicular steatosis (tailed arrows), pyknotic nuclei (P), portal tract (PT) infiltrated with mononuclear inflammatory cells (winding arrows), fibrous septa (curved arrows) radiating from the portal tract. Dilated blood sinusoids (BS) in B and pseudo lobules (PS) in C could be also seen. D, d & E, e (spontaneous reversion group 2 & 4 wks respectively): showing portal tract (PT), infiltrated with mononuclear inflammatory cells (winding arrows) with fibrous septa (curved arrow), pseudolobules (PS) and some pyknotic nuclei (P). In e some hepatocytes (H) appear normal while others still show degenerative changes; micro and macrovesicular steatosis (tailed arrows) & dilated blood sinusoids (BS) could be also seen