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Table 2 Univariate analysis of variables associated with infection

From: Clinical Data based XGBoost Algorithm for infection risk prediction of patients with decompensated cirrhosis: a 10-year (2012–2021) Multicenter Retrospective Case-control study

Variables

Training set

Infection group

Non-infection group

P value

(N = 4353)

(N = 2266)

(N = 2087)

Age

56.00(49.00,67.00)

56.00(49.00,66.00)

56.00(50.00,67.00)

0.544

Sex

3165(72.71)

1710(75.46)

1455(69.72)

< 0.001

Hypertension

497(11.42)

241(10.64)

256(12.27)

0.100

Diabetes

722(16.59)

412(18.18)

310(14.85)

0.004

Smoking

2057(47.25)

1116(49.25)

941(45.09)

0.007

Drinking

1997(45.88)

1107(48.85)

890(42.64)

< 0.001

Primary liver cancer

474(10.89)

217(9.58)

257(12.31)

0.004

Family history of liver disease

944(21.69)

497(21.93)

447(21.42)

0.708

HBV

2798(64.28)

1476(65.14)

1322(63.34)

0.230

HCV

184(4.23)

83(3.66)

101(4.84)

0.064

Alcoholic

614(14.11)

369(16.28)

245(11.74)

< 0.001

Autoimmunity

339(7.79)

149(6.58)

190(9.10)

0.002

GIB

798(18.33)

520(22.95)

278(13.32)

< 0.001

Ascites

164(3.77)

84(3.71)

80(3.83)

0.890

HE

266(6.11)

212(9.36)

54(2.59)

< 0.001

HF

623(14.31)

550(24.27)

73(3.50)

< 0.001

TP (IQR, g/L)

64.70(58.60,71.70)

62.20(56.50,68.30)

67.60(61.20,74.20)

< 0.001

TB (IQR, umol/L)

29.60(17.30,71.80)

46.20(21.60,164.40)

22.50(14.70,37.60)

< 0.001

Hemoglobin (IQR, g/L)

108.00(84.00,127.00)

103.00(81.00,123.00)

113.00(89.00,131.00)

< 0.001

Na (IQR, mmol/L)

139.30(136.20,141.70)

138.00(134.60,141.00)

140.20(138.00,142.20)

< 0.001

 K (IQR, mmol/L)

3.87(3.55,4.19)

3.84(3.46,4.23)

3.90(3.61,4.14)

0.003

ALB (IQR, g/L)

31.20(27.30,35.40)

29.00(26.00,32.78)

33.70(29.90,38.00)

< 0.001

PTA (IQR, %)

63.60(49.00,78.00)

54.80(40.00,68.93)

72.00(60.00,85.00)

< 0.001

BUN (IQR, mmol/L)

5.40(4.11,7.36)

5.80(4.22,8.42)

5.13(4.03,6.66)

< 0.001

Cr (IQR, umol/L)

67.20(56.10,81.70)

69.00(57.43,87.10)

65.80(54.95,76.95)

< 0.001

RBC count (IQR, ×109/L)

3.51(2.88,4.11)

3.32(2.73,3.96)

3.69(3.08,4.26)

< 0.001

WBC count (IQR, ×109/L)

4.32(2.99,6.35)

5.20(3.43,7.95)

3.73(2.70,5.03)

< 0.001

NLR (IQR)

3.37(2.08,5.82)

4.94(2.96,7.95)

2.43(1.62,3.62)

< 0.001

  1. HBV: hepatitis B virus; HCV: hepatitis C virus; GIB: gastrointestinal bleeding; HE: hepatic encephalopathy; HF: hepatic failure; TP: total protein; TB: total bilirubin; Na: blood sodium; K: blood potassium; ALB: albumin; PTA: prothrombin activity; BUN: blood urea nitrogen; Cr: creatinine; RBC: Red blood cell; WBC: white blood cell; NLR: neutrophils to lymphocytes ratio; IQR: interquartile range