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Table 1 Comparison of patients’ characteristics according to the age

From: Acute cholecystitis in old adults: the impact of advanced age on the clinical characteristics of the disease and on the surgical outcomes of laparoscopic cholecystectomy

Variable

Total

(n = 1876)

Age < 60

(n = 723)

60 ≤ Age < 80

(n = 867)

Age ≥ 80

(n = 286)

P-value

Age, mean years (SD)

62.7 (16.2)

45.6 (9.9)

69.9 (5.7)

84.0 (3.6)

< 0.001

Female, n (%)

809 (43.1)

325 (45.0)

324 (37.4)

160 (55.9)

< 0.001

BMI, mean kg/m2 (SD)

24.8 (3.6)

25.5 (3.8)

24.7 (3.2)

23.0 (3.4)

< 0.001

Charlson age comorbidity index, n (%)

    

< 0.001

   0–5

   ≥ 6

1766 (94.1)

110 (5.9)

723 (100.0)

0 (0.0)

836 (96.4)

31 (3.6)

207 (72.4)

79 (27.6)

 

ASA PS classification, n (%)

    

< 0.001

   1–2

1364 (72.7)

679 (93.9)

573 (66.1)

112 (39.2)

 

   3–5

512 (27.3)

44 (6.1)

294 (33.9)

174 (60.8)

 

Previous abdominal surgery (+), n (%)

336 (17.9)

137 (18.9)

151 (17.4)

48 (16.8)

0.631

Severity according to the TG 18, n (%)

    

< 0.001

   Grade I

1374 (73.2)

611 (84.5)

592 (68.3)

171 (59.8)

 

   Grade II

435 (23.2)

109 (15.1)

236 (27.2)

90 (31.5)

 

   Grade III

67 (3.6)

3 (0.4)

39 (4.5)

25 (8.7)

 

Acalculous cholecystitis on preoperative imaging, n (%)

520 (27.7)

164 (22.7)

256 (29.5)

100 (35.0)

< 0.001

Combined CBD stone on preoperative imaging, n (%)

353 (18.8)

113 (15.6)

169 (19.5)

71 (24.8)

0.003

Preoperative laboratory findings

     

   WBC, mean 103/mm3 (SD)

11.7 (5.2)

10.9 (4.5)

12.2 (5.6)

12.6 (5.4)

< 0.001

   Hemoglobin, mean g/dL (SD)

13.4 (1.7)

13.9 (1.7)

13.3 (1.6)

12.5 (1.8)

< 0.001

   Platelet, mean 103/mm3 (SD)

223.8 (72.3)

242.7 (66.0)

211.9 (72.9)

211.8 (76.1)

< 0.001

   PT, mean INR (SD)

1.11 (0.17)

1.07 (0.12)

1.12 (0.15)

1.16 (0.28)

< 0.001

   Creatinine, mean mg/dL (SD)

0.95 (0.61)

0.82 (0.52)

1.01 (0.67)

1.07 (0.58)

< 0.001

   Albumin, mean g/dL (SD)

3.70 (0.58)

4.01 (0.48)

3.59 (0.54)

3.21 (0.47)

< 0.001

   AST, mean IU/L (SD)

129.8 (273.9)

119.1 (247.1)

132.2 (300.4)

149.6 (252.7)

0.263

   ALT, mean IU/L (SD)

104.7 (191.1)

115.1 (201.2)

99.8 (197.0)

93.1 (138.7)

0.152

   Total bilirubin, mean mg/dL (SD)

1.77 (1.83)

1.60 (1.74)

1.87 (1.94)

1.88 (1.69)

0.007

   CRP, mean mg/dL (SD)

8.68 (10.34)

5.98 (8.98)

9.88 (10.70)

11.42 (10.84)

< 0.001

Preoperative PTGBD, n (%)

1020 (54.4)

271 (37.5)

529 (61.0)

220 (76.9)

< 0.001

  1. SD: standard deviation; BMI, body mass index; ASA PS: American Society of Anesthesiologists physical status; TG 18: Tokyo guideline 2018; CBD: common bile duct; WBC: white blood cell; PT INR: prothrombin time international normalized ratio; AST: aspartate aminotransferase; ALT: alanine aminotransferase; CRP: C-reactive protein; PTGBD: percutaneous transhepatic gallbladder drainage