Long non-coding RNA CASC7 is a promising serum biomarker for hepatocellular carcinoma

BMC Gastroenterology

Table 1 Correlation between CASC7 expression and clinicopathological characteristics of hepatocellular carcinoma

Clinical characteristics	Case number	lncRNA CASC7 expression	p value
Gender			0.844
Male	70	11.33 ± 10.31
Female	10	10.56 ± 12.1
Age (years)			0.132
40–60	45	11.03 ± 10.04
< 40 or > 60	35	11.49 ± 11.14
HBV infection			0.679
No	17	8.88 ± 8.72
Yes	63	11.87 ± 10.87
HBV-DNA (IU/ml)			0.152
< 100	17	9.32 ± 6.5
≥ 100	63	11.75 ± 11.29
AFP (ng/ml)			0.693
< 200	41	10.55 ± 11.2
≥ 200	39	11.95 ± 9.74
Tumor number			0.005^**
Solitary	32	7.11 ± 5.51
Multiple	48	13.99 ± 12.04
Cirrhosis			0.559
No	35	10.77 ± 10.22
Yes	45	11.22 ± 9.21
Intrahepatic metastasis			< 0.001^***
No	47	6.69 ± 5.03
Yes	33	17.19 ± 11.16
Tumor size			0.007^**
< 5	20	6.39 ± 4.9
≥ 5	53	13.13 ± 10.74
BCLC			0.213
A + B	27	8.61 ± 8.18
C + D	52	12.28 ± 10.2
TNM stage			0.008^**
I+II	28	6.77 ± 5.45
III+IV	50	13.67 ± 10.61
Child-Pugh			0.834
A	43	10.42 ± 9.1
B	35	11.7 ± 10.5
C	2	12.2 ± 5.6

Note: Values are mean ± SD. **p < 0.01, ***p < 0.001
CASC7: cancer susceptibility candidate 7, HBV: hepatitis B virus, AFP: alpha fetoprotein, BCLC: Barcelona Clinic Liver Cancer, TNM: tumor node metastasis

ISSN: 1471-230X