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Table 2 Comparisons of ROC curve parameters between CASC7 and AFP

From: Long non-coding RNA CASC7 is a promising serum biomarker for hepatocellular carcinoma

Factors

Cut-off value

AUC (95%CI)

Sensitivity

Specificity

Youden index

p value

MultipleversusSolitary

      

CASC7

7.6

0.713 (0.600-0.826)

76.10%

57.60%

0.337

0.001

AFP

8.6

0.567 (0.437–0.697)

87%

30.30%

0.173

0.311

IM-positiveversusnegative

      

CASC7

12.84

0.811 (0.714–0.909)

60.60%

91.50%

0.521

< 0.001

AFP

915

0.545 (0.416–0.675)

42.40%

72.30%

0.147

0.491

Tumor size ≥ 5versus < 5

      

CASC7

12.36

0.709 (0.583–0.836)

43.40%

95%

0.384

0.006

AFP

107

0.623 (0.480–0.766)

62.30%

65%

0.273

0.107

TNM III+IVversusI+II

      

CASC7

11.68

0.719 (0.604–0.834)

48%

89.30%

0.373

0.001

AFP

724

0.616 (0.488–0.744)

48%

78.60%

0.266

0.09

HCCversusCHB

      

CASC7

7.24

0.853 (0.794–0.913)

63.80%

100%

0.638

< 0.001

AFP

13

0.927 (0.886–0.969)

75%

98.50%

0.735

< 0.001

HCCversusNormal

      

CASC7

8.16

0.757 (0.678–0.836)

57.50%

100%

0.575

< 0.001

AFP

4

0.981 (0.966–0.997)

91.30%

96.30%

0.876

< 0.001

HCCversusCHB and Normal

      

CASC7

7.24

0.808 (0.742–0.874)

63.80%

95.20%

0.590

< 0.001

AFP

5.57

0.957 (0.931–0.983)

85%

93.90%

0.789

< 0.001

  1. ROC: Receiver operating characteristics, CASC7: cancer susceptibility candidate 7, AFP: alpha fetoprotein, AUC: area under the curve, CI: confidence interval, IM: intrahepatic metastasis, TNM: tumor node metastasis, CHB: chronic hepatitis B
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BMC Gastroenterology

ISSN: 1471-230X

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