Risk prediction of second primary malignancies in patients after rectal cancer: analysis based on SEER Program

Sun, Yong-Chao; Zhao, Zi-Dan; Yao, Na; Jiao, Yu-Wen; Zhang, Jia-Wen; Fu, Yue; Shi, Wei-Hai

doi:10.1186/s12876-023-02974-2

BMC Gastroenterology

Table 2 Clinicopathological characteristics of SPM patients with RC

From: Risk prediction of second primary malignancies in patients after rectal cancer: analysis based on SEER Program

Variables	Training set		Validation set		χ²	P value
Variables	(n = 585)		(n = 156)
	N	%	N	%
Site of SPMs					0.75	0.980
Lung and Bronchus	106	18.1	30	19.2
Urinary Bladder	88	8.7	24	7.7
Rectum	68	43.4	15	44.9
Melanoma of the Skin	51	11.6	12	9.6
Sigmoid Colon	18	3.1	5	3.2
Others	254	15.0	70	15.4
Histology of SPMs					6.54	0.257
Squamous Cell Neoplasms	130	22.2	28	17.9
Adenomas and Adenocarcinomas	114	19.5	25	16.0
Transitional Cell Papilloma and Carcinomas	90	15.4	22	14.1
Cystic, Mucinous and Serous Neoplasms	64	10.9	27	17.3
Nevi and Melanomas	51	8.7	13	8.3
Others	136	23.2	41	26.3
Age(years)					0.79	0.853
<60	152	26.0	42	26.9
60–69	190	32.5	47	30.1
70–79	214	36.6	61	39.1
≥ 80	29	5.0	6	3.8
Race					5.29	0.071
White	484	82.7	127	81.4
Black	65	11.1	12	7.7
Others	36	6.2	17	10.9
Stage-T					2.81	0.590
Ta	141	24.1	34	21.8
T1	186	31.8	42	26.9
T2	122	20.9	38	24.4
T3	89	15.2	26	16.7
T4	47	8.0	16	10.3
Stage-N					5.15	0.161
N0	482	82.4	113	74.4
N1	55	9.4	22	14.1
N2	43	7.4	16	10.3
N3	5	0.9	5	1.3
Stage-M					0.29	0.593
M0	528	90.3	143	91.7
M1	57	9.7	13	8.3
Stage-T of RC					2.71	0.608
Ta	74	12.6	24	15.4
T1	140	23.9	34	21.8
T2	87	14.9	29	18.6
T3	254	43.4	63	40.4
T4	30	5.1	6	3.8
Stage-N of RC					3.72	0.155
N0	437	74.7	106	67.9
N1	110	18.8	34	21.8
N2	38	6.5	16	10.3
Stage-M of RC					0.91	0.341
M0	552	94.4	144	92.3
M1	33	5.6	12	7.7
SPMs Surgical history
Yes	422	72.1	113	72.4	0.005	0.941
No	163	27.9	43	27.6
Surgical history of RC					0.35	0.554
Yes	511	87.4	139	89.1
No	74	12.6	17	10.9
Histology of RC					0.75	0.689
Others	70	12.0	19	12.2
Ade	436	74.5	120	76.9
Cystic, Mucinous and Serous Neoplasms	79	13.5	17	10.9
SPMs radiation record					0.58	0.445
Yes	151	25.8	45	28.8
No	434	74.19	111	71.2
Radiation record of RC					0.83	0.362
Yes	291	49.7	84	53.8
No	294	50.3	72	46.2
SPMs chemotherapy record					0.96	0.328
Yes	215	36.8	64	41.0
No	370	63.2	92	59.0
Chemotherapy record of RC					1.06	0.303
Yes	318	54.4	92	59.0
No	267	45.6	64	41.0
SPMs tumor size(cm)					5.45	0.141
0–3	394	67.4	97	62.2
3–5	86	14.7	32	20.5
5–10	78	13.3	16	10.3
≥ 10	27	4.6	11	7.1
SPMs grade					4.73	0.316
Well	56	9.6	9	5.8
Moderately	183	31.3	41	26.3
Poorly	94	16.1	29	18.6
Undifferentiated	45	7.7	15	9.6
Unknown	207	35.4	62	39.7

Abbreviations: SPMs: second primary malignancies; RC: rectal cancer, Ade: adenomas and adenocarcinomas

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