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Table 3 Univariate and multivariate Cox analysis of SPMs patients after RC in the training and validation set

From: Risk prediction of second primary malignancies in patients after rectal cancer: analysis based on SEER Program

Variables

Univariate analysis

 

Multivariate analysis

 

HR

CI (95%)

P value

HR

CI (95%)

P value

Site of SPMs

  

0.009

  

0.108

 Lung and Bronchus

1.000

  

1.000

  

 Urinary Bladder

0.383

0.276–0.530

<0.001

1.651

0.735–3.713

0.225

 Rectum

0.507

0.366–0.701

<0.001

1.020

0.648–1.605

0.932

 Melanoma of the Skin

0.349

0.229–0.530

<0.001

0.217

0.029–1.630

0.137

 Sigmoid Colon

0.427

0.243–0.748

<0.001

0.854

0.450–1.621

0.629

 Others

0.522

0.410–0.665

<0.001

0.840

0.619–1.140

0.263

Age(years)

  

<0.001

  

<0.001

 <60

1.000

  

1.000

  

 60–69

1.431

1.099–1.863

0.008

1.422

1.074–1.883

0.014

 70–79

1.758

1.370–2.256

<0.001

1.713

1.297–2.263

<0.001

 ≥ 80

2.499

1.624–3.846

<0.001

2.801

1.763–4.450

<0.001

Stage-T

  

<0.001

  

0.003

 Ta

1.000

  

1.000

  

 T1

1.028

0.786–1.345

0.839

0.819

0.586–1.146

0.244

 T2

1.388

1.045–1.844

0.024

0.835

0.577–1.207

0.337

 T3

1.545

1.145–2.084

0.004

1.159

0.769–1.748

0.480

 T4

3.340

2.377–4.693

<0.001

1.390

0.898–2.153

0.140

Stage-N

  

<0.001

  

0.012

 N0

1.000

  

1.000

  

 N1

1.618

1.222–2.143

<0.001

0.926

0.660–1.299

0.655

 N2

2.313

1.676–3.192

<0.001

1.534

1.071–2.197

0.020

 N3

3.369

1.668–6.802

<0.001

2.011

0.923–4.380

0.079

Stage-M

  

<0.001

  

<0.001

 M0

1.000

  

1.000

  

 M1

3.748

2.849–4.931

<0.001

2.523

1.800-3.537

<0.001

Stage-T of RC

  

0.005

  

0.094

 Ta

1.000

  

1.000

  

 T1

0.847

0.610–1.176

0.322

0.841

0.593–1.192

0.330

 T2

1.036

0.730–1.471

0.843

1.106

0.740–1.653

0.623

 T3

1.132

0.841–1.524

0.415

1.009

0.682–1.495

0.963

 T4

2.028

1.295–3.178

0.002

1.917

1.145–3.211

0.013

Stage-N of RC

  

0.017

  

0.721

 N0

1.000

  

1.000

  

 N1

1.187

0.942–1.496

0.146

0.975

0.753–1.261

0.844

 N2

1.848

1.324–2.578

<0.0001

1.314

0.894–1.932

0.164

Stage-M of RC

  

<0.001

  

<0.001

 M0

1.000

  

1.000

  

 M1

3.828

2.747–5.336

<0.001

3.113

2.144–4.521

<0.001

SPMs surgical history

  

<0.001

  

<0.001

 Yes

1.000

  

1.000

  

 No

2.403

1.974–2.924

<0.001

2.056

1.552–2.725

<0.001

SPMs radiation record

  

<0.001

  

0.129

 Yes

1.000

  

1.000

  

 No

0.707

0.577–0.866

<0.001

1.217

0.949–1.560

0.122

SPMs chemotherapy record

  

<0.001

  

0.177

 Yes

1.000

  

1.000

  

 No

0.581

0.482-0.700

<0.001

0.874

0.682–1.120

0.287

SPMs tumor size(cm)

  

<0.001

  

0.140

 0–3

1.000

  

1.000

  

 3–5

1.616

1.262–2.069

<0.001

1.377

1.032–1.839

0.030

 5–10

2.005

1.544–2.602

<0.001

1.365

1.007–1.850

0.045

 ≥ 10

0.965

0.613–1.520

0.879

0.792

0.472–1.330

0.378

  1. Abbreviations: SPMs: second primary malignancies; RC: rectal cancer
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BMC Gastroenterology

ISSN: 1471-230X

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