Fig. 3

ROC curve analysis using plasma anti-HBc levels for discriminating CHB patients that achieved HBsAg seroclearance and patients that remain HBsAg (+). All four ROC curves reached statistical significance at p < 0.001. (A) Plasma anti-HBc level at 10–8 years before HBsAg seroclearance yielded an AUC (the areas under the ROC curve) of 0.737 [95% CI 0.668–0.806]. (B) Plasma anti-HBc level at 8–5 years before HBsAg seroclearance yielded an AUC of 0.778 [95% CI 0.718–0.838]. (C) Plasma anti-HBc level at 3–1 years before HBsAg seroclearance yielded an AUC of 0.743 [95% CI 0.678–0.807] (D) Plasma anti-HBc level at 1–0 years before HBsAg seroclearance yielded an AUC of 0.819 [95% CI 0.764–0.873]