Table 6 Univariate and multivariable Cox analysis for OS of the transverse-sided EOCCs

Sex

 Female

Ref

 Male

0.815 (0.483–1.377)

0.445

Histology

 Non-specific adenocarcinoma

Ref

 Specific adenocarcinoma

1.214 (0.657–3.965)

0.328

 Others

2.041 (0.186–4.813)

0.211

Pathologic stage

 I-II

Ref

 III-IV

9.874 (5.884–16.569)

 < 0.001^*

4.789 (2.453–9.353)

 < 0.001^*

Surgery of Primary Site

 No

Ref

 Yes

2.593 (0.773–5.243)

0.487

Reginal lymph node dissection

 No

Ref

 Yes

0.175 (0.065–0.475)

0.001^*

0.167 (0.048–0.583)

0.005^*

Radiation

 No

Ref

 Yes

2.848 (0.177–5.813)

0.460

Chemotherapy

 No/unknown

Ref

 Yes

0.369 (0.186–0.734)

0.005^*

0.526 (0.283–0.976)

0.042^*

Bone metastasis

 No

Ref

 Yes

8.157 (0.842–79.012)

0.070

Liver metastasis

 No

Ref

 Yes

14.196 (8.261–24.395)

 < 0.001^*

4.610 (2.445–8.691)

 < 0.001^*

Lung metastasis

 No

Ref

 Yes

11.216 (2.355–20.419)

0.002^*

3.08 (0.571–16.616)

0.191

Grade

 Well and moderate

Ref

 Poor

2.985 (1.971–4.520)

 < 0.001^*

2.566 (1.517–4.342)

 < 0.001^*

Pretreatment CEA level

 Negative

Ref

 Elevated

6.558 (4.312–9.975)

 < 0.001^*

3.648 (2.216- 6.006)

 < 0.001^*

Perineural invasion

 No

Ref

 Yes

4.439 (2.768–7.117)

 < 0.001^*

2.710 (1.494- 4.919)

0.001^*

Tumor size(mm)

  < 54.9

Ref

  > 54.9

0.391 (0.224–0.681)

0.001^*

0.853 (0.590–1.233)

0.398