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Table 2 Univariate and multivariate analyses for liver steatosis severity in different sex and menopausal status populations

From: Sex- and reproductive status-specific relationships between body composition and non-alcoholic fatty liver disease

 

Unadjusted

Model 1

Model 2

 

Model 3

 
 

OR (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

Men

        

WC (cm)

1.12 (1.09, 1.13)

<0.001

1.09 (1.05, 1.15)

< 0.001

1.07 (1.02, 1.13)

0.008

1.07 (1.02, 1.12)

0.011

VFA ≥ 100 cm²

7.22 (4.6, 11.31)

<0.001

1.62 (0.88, 2.98)

0.121

1.31 (0.70, 2.45)

0.395

1.33 (0.70, 2.49)

0.382

ASMI (kg/m²)

3.05 (2.35, 3.95)

<0.001

0.83 (0.51, 1.35)

0.461

0.87 (0.53, 1.42)

0.576

0.85 (0.51, 1.40)

0.525

FFM/FM

0.19 (0.13, 0.28)

<0.001

0.50 (0.31, 0.83)

0.007

0.55 (0.33, 0.92)

0.023

0.52 (0.31, 0.89)

0.017

Pre-menopausal women

        

WC (cm)

1.07 (1.045, 1.09)

<0.001

1.07 (1.03, 1.11)

0.001

1.04 (0.998, 1.08)

0.059

1.04 (0.996, 1.08)

0.073

VFA ≥ 100 cm²

4.00 (2.02, 7.94)

<0.001

1.62 (0.76, 3.47)

0.210

1.47 (0.67, 3.21)

0.339

1.62 (0.74, 3.58)

0.228

ASMI (kg/m²)

1.96 (1.56, 2.47)

<0.001

1.08 (0.74, 1.56)

0.690

0.94 (0.64, 1.39)

0.763

0.95 (0.64, 1.41)

0.798

FFM/FM

0.28 (0.17, 0.46)

<0.001

0.83 (0.44, 1.55)

0.552

0.72 (0.36, 1.43)

0.345

0.67 (0.34, 1.35)

0.265

Post-menopausal women

        

WC (cm)

1.08 (1.04, 1.13)

<0.001

1.08 (0.98, 1.19)

0.103

1.09 (0.99, 1.20)

0.094

1.10 (0.99, 1.21)

0.076

VFA ≥ 100 cm²

5.97 (2.07, 17.21)

0.001

3.78 (1.13, 12.65)

0.031

3.89 (1.05, 14.36)

0.041

4.16 (1.09, 15.90)

0.037

ASMI (kg/m²)

1.94 (1.23, 3.07)

0.005

0.74 (0.31, 1.75)

0.495

0.76 (0.32, 1.84)

0.549

0.94 (0.38, 2.30)

0.884

FFM/FM

0.13 (0.05, 0.39)

<0.001

0.22 (0.05, 1.01)

0.051

0.39 (0.09, 1.75)

0.219

0.42 (0.10, 1.75)

0.233

  1. Multivariate model 1, adjusted for age and body mass index (BMI)
  2. Multivariate model 2, adjusted for liver enzymes and dyslipidemia based on model 1
  3. Multivariate model 3, adjusted for type 2 diabetes mellitus (T2DM) and homeostasis model assessment of insulin resistance (HOMA-IR) based on model 2
  4. OR: odds ratio; CI: confidence interval; WC: waist circumference; VFA: visceral fat area; ASMI: appendicular skeletal muscle mass index; FFM/FM: fat free mass to fat mass ratio