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Table 3 Univariate and multivariate analyses for liver fibrosis severity in different sex and menopausal status populations

From: Sex- and reproductive status-specific relationships between body composition and non-alcoholic fatty liver disease

 

Unadjusted

Model 1

Model 2

 

Model 3

 
 

OR (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

Men

        

WC (cm)

1.07 (1.05, 1.08)

<0.001

1.06 (1.03, 1.10)

< 0.001

1.04 (1.01, 1.08)

0.017

1.05 (1.01, 1.09)

0.013

VFA ≥ 100 cm²

7.81 (4.47, 13.64)

<0.001

3.92 (2.05, 7.51)

< 0.001

3.59 (1.82,7.07)

< 0.001

3.92 (1.97, 7.81)

< 0.001

ASMI (kg/m²)

2.16 (1.74, 2.69)

<0.001

0.99 (0.64, 1.53)

0.954

0.92 (0.58, 1.44)

0.709

0.89 (0.56, 1.39)

0.598

FFM/FM

0.32 (0.22, 0.45)

<0.001

0.76 (0.47, 1.22)

0.262

0.85 (0.54, 1.33)

0.470

0.79 (0.49, 1.29)

0.351

Pre-menopausal women

        

WC (cm)

1.07 (1.05, 1.10)

<0.001

1.03 (0.98, 1.08)

0.209

1.00 (0.95, 1.05)

0.943

1.01 (0.96, 1.06)

0.828

VFA ≥ 100 cm²

3.02 (1.16, 7.87)

0.024

0.87 (0.31, 2.48)

0.798

1.10 (0.33, 3.62)

0.874

1.16 (0.35, 3.84)

0.804

ASMI (kg/m²)

2.11 (1.62, 2.75)

<0.001

0.84 (0.53, 1.33)

0.449

0.72 (0.44, 1.17)

0.185

0.75 (0.45, 1.23)

0.250

FFM/FM

0.15 (0.07, 0.32)

<0.001

0.78 (0.31, 1.96)

0.600

0.58 (0.21, 1.61)

0.299

0.60 (0.22, 1.66)

0.322

Post-menopausal women

        

WC (cm)

1.05 (1.00, 1.10)

0.036

0.93 (0.83, 1.04)

0.199

0.93 (0.82, 1.05)

0.229

0.93 (0.82, 1.05)

0.237

VFA ≥ 100 cm²

2.70 (0.74, 9.89)

0.133

0.98 (0.22, 4.46)

0.981

0.73 (0.14, 3.77)

0.706

0.71 (0.14, 3.69)

0.686

ASMI (kg/m²)

1.79 (1.02, 3.16)

0.044

0.82 (0.26, 2.64)

0.745

0.98 (0.32, 3.03)

0.970

1.01 (0.31, 3.22)

0.993

FFM/FM

0.20 (0.05, 0.82)

0.025

0.74 (0.15, 3.59)

0.713

0.86 (0.28, 2.60)

0.786

0.89 (0.32, 2.43)

0.815

  1. Multivariate model 1, adjusted for age and body mass index (BMI)
  2. Multivariate model 2, adjusted for liver enzymes and dyslipidemia based on model 1
  3. Multivariate model 3, adjusted for type 2 diabetes mellitus (T2DM) and homeostasis model assessment of insulin resistance (HOMA-IR) based on model 2
  4. OR: odds ratio; CI: confidence interval; WC: waist circumference; VFA: visceral fat area; ASMI: appendicular skeletal muscle mass index; FFM/FM: fat free mass to fat mass ratio