All patients (n = 190) | Post-delivery flare (n = 19) | No post-delivery flare (n = 171) | p value | |
---|---|---|---|---|
Age at IBD diagnosis | Mean 21.5 +/- 7 Median 22 (IQR 17–26) | 22 +/- 7 22 (17–25) | 22 +/- 6 31 (17–26) | 0.818 |
Age at first delivery | Mean 30 +/- 5 Median 30 (IQR 26–33) | 30 +/- 7 30 (27–34) | 30 +/- 5 30 (26–33) | 0.840 |
Interval between diagnosis and first delivery (years) | Median 8 (4–13) Mean 9 +/- 6 | 9 (5–10) 9 +/- 5 | 8 (4–13) 9 +/- 7 | 0.894 |
BMI at delivery | Mean 27 +/- 6 Median 25 (23–30) | 29 +/- 8 27 (IQR 23–32) | 26 +/- 6 25 (22.5–29) | 0.086 |
IBD diagnosis | 0.026 | |||
CD UC | 154 (81%) 36 (19%) | 19 (100%) 0 | 135 (78%) 36 (21%) | |
Comorbidities | ||||
Hypertension Diabetes Dyslipidemia Chronic kidney failure Cardiac disease COPD Chronic liver disease Vasculopathy | 3 (2%) 3 (2%) 1 (0.5%) 1 (0.5%) 4 (2%) 6 (3%) 3 (2%) 1 (0.5%) | 1 (5%) 1 (5%) 0 1 (5%) 1 (5%) 0 0 0 | 2 (1%) 2 (1%) 1 (1%) 0 3 (2%) 6 (3.5%) 3 (2%) 1 (1%) | 0.174 0.174 0.738 0.003 0.312 0.407 0.561 0.738 |
Smoking | 51 (27%) | 7 (37%) | 44 (26%) | 0.300 |
Previous abdominal surgery for IBD TPC + EI TPC + IPAA ICR or BR Stricturoplasty TC + IR anastomosis Colon resection Other | 71 (37%) 7 (4%) 13 (7%) 42 (22%) 1 (0.5%) 3 (2%) 9 (5%) 1 (0.5%) | 11 (58%) 2 (10%) 1 (5%) 7 (37%) 0 0 2 (10%) 0 | 60 (35%) 5 (3%) 12 (7%) 35 (20%) 1 (1%) 3 (2%) 7 (4%) 1 (1%) | 0.051 0.095 0.774 0.103 0.738 0.561 0.210 |
Montreal classification – Age (years) | 0.740 | |||
1 < 16 2 17–40 years 3 > 40 years | 34/154 (22%) 116/154 (76%) 3/154 (2%) | 5 (26%) 14 (73%) 0 | 29 922%) 102 (76%) 3 (2%) | |
Montreal classification – Behavior | 0.108 | |||
1 Nonpenetrating, nonstricturing 2 Stricturing 3 Penetrating | 80/154 (52%) 47/154 (30%) 27/154 (17%) | 6 (32%) 7 (37%) 6 (32%) | 74 (54%) 40 (30%) 21 (16%) | |
Montreal classification – Location | 0.047 | |||
1 Ileal 2 Colonic 3 Ileocolonic | 43/154 (28%) 32/154 (21%) 79/154 (51%) | 1 (5%) 4 (21%) 14 (74%) | 42 (31%) 28 921%) 65 (48%) | |
Montreal classification – UC | - | |||
1 Proctitis 2 Left-sided 3 Pancolitis | 8/36 (22%) 6/36 (17%) 22/36 (61%) | 8/36 (22%) 6/36 (17%) 22/36 (61%) | ||
Perianal disease Perianal fistula Rectovaginal fistula Both | 40 (21%) 33 (17%) 3 (2%) 4 (2%) | 15 (79%) 12/15 (80%) 2/15 (13%) 1/15 (7%) | 25 (15%) 21/25 (84%) 1/25 (4%) 3/25 (12%) | < 0.001 0.503 |
Surgery for perianal disease EUA Abscess drainage Seton Fistulotomy LIFT Mucosal advancement flap Gracilis flap Martius flap 10 Other | 28/40 (70%, 14% of entire cohort) 9 (5%) 21 (11%) 23 (12%) 8 (4%) 2 (1%) 4 (2%) 1 (0.5%) 0 2 (1%) | 12/15 (80%, 63% of entire cohort) 4 (21%) 10 (53%) 10 (53%) 4 (21%) 2 (10%) 2 (10%) 0 0 1 (5%) | 16/25 (64%) 5 (3%) 11 (6%) 13 (8%) 4 (2%) 0 2 (1%) 1 (1%) 1 (1%) 1 (1%) | 0.385 |
Deliveries | 0.251 | |||
One Two Three or more | 80 (42%) 88 (46%) 22 (12%) | 9 (47%) 10 (53%) 0 | 71 (41%) 78 (46%) 22 (13%) | |
Median follow up (months) | 65 (IQR 38–95) | 98 (40–110) | < 0.001 |