Table 4 Risk factors for overall survival according to Cox proportional hazards regression model

Age

367

 <  = 65

163

Reference

 > 65

204

1.620 (1.154–2.276)

0.005

1.571 (1.029–2.398)

0.036

Pathologic stage

347

Stage I

50

Reference

Stage II&Stage III&Stage IV

297

2.247 (1.210–4.175)

0.010

1.004 (0.357–2.826)

0.994

T stage

362

T1

18

Reference

T2&T3&T4

344

8.829 (1.234–63.151)

0.030

1,533,097.7526 (0.000-Inf)

0.995

N stage

352

N0

107

Reference

N1&N2&N3

245

1.925 (1.264–2.931)

0.002

2.023 (1.022—4.004)

0.043

M stage

352

M0

327

Reference

M1

25

2.254 (1.295–3.924)

0.004

1.300 (0.575–2.943)

0.528

Histologic grade

361

G1

10

Reference

G2&G3

351

1.957 (0.484–7.910)

0.346

Primary therapy outcome

313

CR

229

Reference

PD&SD&PR

84

4.228 (2.905–6.152)

 < 0.001

4.130 (2.624–6.500)

 < 0.001

Helicobacter pylori infection

162

No

144

Reference

Yes

18

0.650 (0.279–1.513)

0.317

Residual tumor

325

R0

294

Reference

R1&R2

31

3.445 (2.160–5.494)

 < 0.001

1.169 (0.613–2.228)

0.636

ITGB1

370

Low

184

Reference

High

186

1.404 (1.008–1.956)

0.045

1.103 (0.695–1.751)

0.676

LUM

370

Low

185

Reference

High

185

1.433 (1.028–1.997)

0.034

1.830 (1.045–3.203)

0.034

COL5A2

370

Low

186

Reference

High

184

1.496 (1.073–2.084)

0.017

0.974 (0.571–1.662)

0.923