LUM as a novel prognostic marker and its correlation with immune infiltration in gastric cancer: a study based on immunohistochemical analysis and bioinformatics

Xu, Wu; Chen, Shasha; Jiang, Qiuju; He, Jinlan; Zhang, Feifei; Wang, Zhuying; Ruan, Caishun; Shi, Bin

doi:10.1186/s12876-023-03075-w

Table 5 Correlation analysis between LUM and relate genes and markers of immune cells in TIMER and GEPIA

From: LUM as a novel prognostic marker and its correlation with immune infiltration in gastric cancer: a study based on immunohistochemical analysis and bioinformatics

Description	Gene markers	TIMER				GEPIA
		None		Purity		Tumour		Normal
		Cor	P	Cor	P	R	P	R	P
CD8 + T cell	CD8A	0.274	***	0.251	***	0.23	***	-0.065	0.710
CD8 + T cell	CD8B	0.142	**	0.129	*	0.12	*	-0.097	0.570
T cell (general)	CD3D	0.244	***	0.211	***	0.19	***	-0.28	0.100
	CD3E	0.242	***	0.211	***	0.22	***	-0.25	0.130
	CD2	0.32	***	0.3	***	0.3	***	-0.2	0.250
B cell	CD19	0.19	***	0.176	***	0.14	**	-0.16	0.370
B cell	CD79A	0.233	***	0.201	***	0.19	***	-0.38	*
Monocyte	CD86	0.496	***	0.473	***	0.47	***	-0.023	0.890
Monocyte	CD115(CSF1R)	0.555	0	0.53	***	0.51	***	0.18	0.300
TAM	CCL2	0.541	0	0.519	***	0.52	***	0.53	**
	CD68	0.305	***	0.269	***	0.28	***	-0.5	**
	IL10	0.494	***	0.476	***	0.48	***	0.25	0.150
M1 Macrophage	INOS(NOS2)	0.029	0.562	0.02	0.697	0.042	0.400	0.2	0.250
	IRF5	0.257	***	0.247	***	0.26	***	-0.54	***
	COX2(PTGS2)	0.297	***	0.307	***	0.32	***	0.68	***
M2 Macrophage	CD163	0.507	0	0.477	***	0.49	***	0.67	***
	VSIG4	0.558	0	0.536	***	0.53	***	0.57	***
	MS4A4A	0.579	0	0.559	***	0.55	***	0.72	***
Neutrophils	CD66b(CEACAM8)	0.016	0.746	0.038	0.465	0.045	0.360	0.27	0.100
	CD11b(ITGAM)	0.496	0	0.48	***	0.47	***	0.49	**
	CCR7	0.27	***	0.238	***	0.24	***	-0.4	*
Natural killer cell	KIR2DL1	0.179	***	0.184	***	0.14	**	0.18	0.300
	KIR2DL3	0.095	0.053	0.083	0.107	0.17	***	0.08	0.640
	KIR2DL4	0.019	0.694	-0.012	0.808	-0.0078	0.880	-0.35	*
	KIR3DL1	0.118	*	0.113	*	0.099	*	0.35	*
	KIR3DL2	0.155	**	0.146	**	0.14	**	-0.07	0.690
	KIR3DL3	-0.088	0.072	-0.081	0.171	-0.1	*	-0.23	0.170
	KIR2DS4	0.07	0.152	0.06	0.243	0.034	0.500	0.17	0.310
Dendritic cell	HLA-DPB1	0.326	***	0.29	***	0.28	***	-0.064	0.710
	HLA-DQB1	0.174	***	0.133	**	0.11	*	-0.22	0.200
	HLA-DRA	0.276	***	0.243	***	0.26	***	-0.093	0.590
	HLA-DPA1	0.284	***	0.249	***	0.24	***	-0.099	0.560
	BCDA-1(CD1C)	0.372	***	0.351	***	0.35	***	-0.095	0.580
	BDCA-4(NRP1)	0.632	0	0.618	***	0.6	***	0.78	***
	CD11c(ITGAX)	0.484	0	0.455	***	0.45	***	0.15	0.390
Th1	T-bet(TBX21)	0.234	***	0.221	***	0.20	***	-0.052	0.760
	STAT4	0.342	***	0.334	***	0.33	***	0.065	0.710
	STAT1	0.102	*	0.093	0.069	0.11	*	0.3	0.078
	IFN-γ(IFNG)	0.069	0.158	0.062	0.229	0.072	0.140	-0.03	0.860
	TNF-α(TNF)	0.137	**	0.109	*	0.15	**	-0.32	0.058
Th2	GATA3	0.323	***	0.314	***	0.27	***	-0.31	0.620
	STAT6	0.109	*	0.102	*	0.11	*	0.31	0.077
	STAT5A	0.386	***	0.384	***	0.35	***	0.72	***
	IL13	0.137	**	0.165	**	0.18	***	0.33	0.053
Tfh	BCL6	0.377	***	0.353	***	0.34	***	0.43	**
Tfh	IL21	0.126	*	0.108	*	0.13	**	-0.15	0.400
Th17	STAT3	0.346	***	0.335	***	0.32	***	0.36	*
Th17	IL17A	-0.134	**	-0.15	**	-0.1	*	-0.31	0.064
Treg	FOXP3	0.278	***	0.253	***	0.27	***	-0.44	**
	CCR8	0.407	***	0.4	***	0.39	***	-0.32	0.060
	STAT5B	0.445	0	0.442	***	0.46	***	0.71	***
	TGFβ(TGFB1)	0.542	***	0.528	***	0.5	***	0.049	0.780
T cell exhaustion	PD-1(PDCD1)	0.17	***	0.151	**	0.14	**	-0.16	0.360
	CTLA4	0.186	***	0.164	**	0.19	***	-0.31	0.063
	LAG3	0.147	**	0.122	*	0.11	*	0.11	0.530
	TIM-3(HAVCR2)	0.503	0	0.482	***	0.47	***	0.21	0.220
	GZMB	0.15	**	0.11	*	0.12	*	-0.15	0.390

TIMER The tumor immune estimation resource, GEPIA Gene expression profiling interactive analysis, CD Cluster of differentiation, TAM Tumor-associated macrophage, Th T helper cell, Tfh Follicular helper T cell, Treg Regulatory T cell, Cor R value of Spearman's correlation, None Correlation without adjustment, Purity correlation adjusted by purity. * P < 0.05; ** P < 0.01; *** P < 0.001

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