Table 3 Duration of tacrolimus administration and renal function

TAC administration period (day)

254.4 ± 251.1

156.6 ± 146.6

0.0489

GFR before TAC administration

90.7 ± 22.3

64.7 ± 14.7

< 0.0001

GFR after TAC administration

 After 2 weeks

86.7 ± 28.4

65.5 ± 16.9

0.0002

 Percent change in eGFR after 2 weeks of TAC administration

−3.6 ± 22.2

3.1 ± 23.7

0.2107

 After 4 weeks

85.4 ± 24.1

65.9 ± 18.6

0.0005

 Percent change in eGFR after 4 weeks of TAC administration

−6.2 ± 24

2.3 ± 19.4

0.0971

 After 12 weeks

82.9 ± 24.3

61.3 ± 16.4

< 0.0001

 Percent change in eGFR after 12 weeks of TAC administration

−10 ± 26.4

−3.2 ± 23.9

0.4459

 After 24 weeks

78.2 ± 21.5

59.6 ± 15.8

0.0001

 Percent change in eGFR after 24 weeks of TAC administration

−15.8 ± 25.4

−10 ± 28.6

0.1851

eGFR after 48 weeks of discontinuation

83.8 ± 18.5

62.8 ± 12.9

< 0.0001

 Percent change after 48 weeks of discontinuation

−5 ± 18.1

−0.9 ± 18.1

0.2752