All eligible participants: Full dataset analysis (n = 34 139) | Participants with complete data on all variables: Complete-case analysis (n = 19 333)a | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
n (%)b | Participants with ≥ 1 adenoma detected at baseline n (%) | Univariable OR (95%CI) | p-value | n (%)b | Participants with ≥ 1 adenoma detected at baseline n (%) | Univariable OR (95%CI) | p-value | Multivariable OR (95%CI)c | p-value | |
Total | 34 139 (100) | 4 104 (12.0) | 19 333 (100) | 2 415 (12.5) | ||||||
Age (IQR), years | 60.3 (57.9–62.8) | 4 104 (12.0) | 1.03 (1.02–1.04) | < 0.001 | 60.5 (58.0–62.9) | 2 415 (12.5) | 1.03 (1.01–1.05) | < 0.001 | 1.03 (1.01–1.04) | 0.002 |
Sex | 34 139 (100) | 4 104 (12.0) | < 0.001 | < 0.001 | < 0.001 | |||||
Male | 18 127 (53.1) | 2 817 (15.5) | 1 | 10 315 (53.4) | 1 665 (16.1) | 1 | 1 | |||
Female | 16 012 (46.9) | 1 287 (8.0) | 0.48 (0.44–0.51) | 9 018 (46.6) | 750 (8.3) | 0.47 (0.43–0.52) | 0.62 (0.56–0.69) | |||
Family history of CRC | 32 356 (94.8) | 3 926 (12.1) | < 0.001 | < 0.001 | < 0.001 | |||||
No | 28 663 (88.6) | 3 381 (11.8) | 1 | 17 123 (88.6) | 2 077 (12.1) | 1 | 1 | |||
Yes | 3 693 (11.4) | 545 (14.8) | 1.29 (1.17–1.43) | 2 210 (11.4) | 338 (15.3) | 1.31 (1.15–1.48) | 1.40 (1.21–1.62) | |||
Centre | 34 139 (100) | 4 104 (12.0) | < 0.001 | < 0.001 | < 0.001 | |||||
1 | 2 413 (7.1) | 207 (8.6) | 1 | 1 607 (8.3) | 139 (8.6) | 1 | 1 | |||
2d | 3 438 (10.1) | 302 (8.8) | 1.03 (0.85–1.23) | - | - | - | - | |||
3 | 2 674 (7.8) | 249 (9.3) | 1.09 (0.90–1.33) | 1 452 (7.5) | 135 (9.3) | 1.08 (0.84–1.39) | 0.91 (0.67–1.23) | |||
4 | 2 131 (6.2) | 209 (9.8) | 1.16 (0.95–1.42) | 1 452 (7.5) | 146 (10.1) | 1.18 (0.93–1.51) | 1.55 (1.14–2.09) | |||
5 | 2 466 (7.2) | 271 (11.0) | 1.32 (1.09–1.59) | 1 844 (9.5) | 189 (10.2) | 1.21 (0.96–1.52) | 0.41 (0.31–0.54) | |||
6 | 2 733 (8.0) | 306 (11.2) | 1.34 (1.12–1.62) | 1 579 (8.2) | 163 (10.3) | 1.22 (0.96–1.54) | 1.23 (0.92–1.65) | |||
7 | 2 516 (7.4) | 282 (11.2) | 1.35 (1.11–1.62) | 1 741 (9.0) | 205 (11.8) | 1.41 (1.12–1.77) | 1.19 (0.89–1.58) | |||
8 | 2 839 (8.3) | 362 (12.8) | 1.56 (1.30–1.86) | 1 486 (7.7) | 190 (12.8) | 1.55 (1.23–1.95) | 0.77 (0.58–1.03) | |||
9 | 2 493 (7.3) | 349 (14.0) | 1.73 (1.45–2.08) | 1 617 (8.4) | 236 (14.6) | 1.80 (1.45–2.25) | 1.39 (1.06–1.83) | |||
10 | 2 532 (7.4) | 370 (14.6) | 1.82 (1.52–2.18) | 1 578 (8.2) | 215 (13.6) | 1.67 (1.33–2.09) | 0.57 (0.43–0.76) | |||
11 | 2 324 (6.8) | 347 (14.9) | 1.87 (1.56–2.25) | 1 202 (6.2) | 185 (15.4) | 1.92 (1.52–2.43) | 0.65 (0.49–0.86) | |||
12 | 2 799 (8.2) | 421 (15.0) | 1.89 (1.58–2.25) | 2 214 (11.5) | 348 (15.7) | 1.97 (1.60–2.43) | 1.11 (0.86–1.44) | |||
13 | 2 781 (8.1) | 429 (15.4) | 1.94 (1.63–2.32) | 1 561 (8.1) | 264 (16.9) | 2.15 (1.73–2.67) | 0.71 (0.54–0.92) | |||
Bowel preparation quality | 33 609 (98.4) | 3 925 (11.7) | 0.05 | 0.001 | < 0.001 | |||||
Excellent | 14 573 (43.4) | 1 690 (11.6) | 1 | 7 819 (40.4) | 924 (11.8) | 1 | 1 | |||
Good | 11 692 (34.8) | 1 431 (12.2) | 1.06 (0.99–1.15) | 6 922 (35.8) | 918 (13.3) | 1.14 (1.03–1.26) | 0.84 (0.74–0.95) | |||
Adequate | 7 060 (21.0) | 769 (10.9) | 0.93 (0.85–1.02) | 4 553 (23.6) | 561 (12.3) | 1.05 (0.94–1.17) | 0.56 (0.49–0.65) | |||
Poor | 284 (0.8) | 35 (12.3) | 1.07 (0.75–1.53) | 39 (0.2) | 12 (30.8) | 3.32 (1.67–6.57) | 2.88 (1.25–6.60) | |||
Insertion time | 20 371 (59.7) | 2 630 (12.9) | < 0.001 | < 0.001 | < 0.001 | |||||
< 2.00 mins | 7 357 (36.1) | 795 (10.8) | 1 | 7 014 (36.3) | 727 (10.4) | 1 | 1 | |||
2.00–2.59 mins | 6 198 (30.4) | 759 (12.2) | 1.15 (1.04–1.28) | 5 894 (30.5) | 702 (11.9) | 1.17 (1.05–1.31) | 1.18 (1.04–1.35) | |||
3.00–3.59 mins | 3 412 (16.7) | 466 (13.7) | 1.31 (1.16–1.48) | 3 221 (16.7) | 424 (13.2) | 1.31 (1.15–1.49) | 1.37 (1.18–1.61) | |||
\(\ge\) 4.00 mins | 3 404 (16.7) | 610 (17.9) | 1.80 (1.61–2.02) | 3 204 (16.6) | 562 (17.5) | 1.84 (1.63–2.07) | 1.96 (1.68–2.29) | |||
Withdrawal time | 20 326 (59.5) | 2 621 (12.9) | < 0.001 | < 0.001 | < 0.001 | |||||
< 2.00 mins | 10 625 (52.3) | 295 (2.8) | 1 | 10 204 (52.8) | 262 (2.6) | 1 | 1 | |||
2.00–2.59 mins | 3 672 (18.1) | 295 (8.0) | 3.06 (2.59–3.61) | 3 479 (18.0) | 266 (7.6) | 3.14 (2.64–3.74) | 3.85 (3.21–4.62) | |||
3.00–3.59 mins | 1 837 (9.0) | 311 (16.9) | 7.14 (6.03–8.44) | 1 740 (9.0) | 289 (16.6) | 7.56 (6.34–9.01) | 9.47 (7.88–11.38) | |||
\(\ge\) 4.00 mins | 4 192 (20.6) | 1 720 (41.0) | 24.36 (21.37–27.78) | 3 910 (20.2) | 1 598 (40.9) | 26.23 (22.84–30.12) | 32.79 (28.22–38.11) | |||
Segment reached | 34 075 (99.8) | 4 098 (12.0) | < 0.001 | < 0.001 | 0.79 | |||||
RM/RS/SC | 128 (0.4) | 16 (12.5) | 1.43 (0.84–2.44) | 53 (0.3) | 8 (15.1) | 1.63 (0.76–3.48) | 1.12 (0.46–2.69) | |||
SD | 7 510 (22.0) | 680 (9.1) | 1 | 4 447 (23.0) | 437 (9.8) | 1 | 1 | |||
DC | 21 327 (62.6) | 2 660 (12.5) | 1.43 (1.31–1.56) | 11 840 (61.2) | 1 519 (12.8) | 1.35 (1.21–1.51) | 1.00 (0.87–1.14) | |||
SF | 3 462 (10.2) | 491 (14.2) | 1.66 (1.47–1.88) | 2 062 (10.7) | 310 (15.0) | 1.62 (1.39–1.90) | 1.12 (0.92–1.38) | |||
TC/HF/AC/CM/TI | 1 648 (4.8) | 251 (15.2) | 1.80 (1.54–2.11) | 931 (4.8) | 141 (15.1) | 1.64 (1.33–2.01) | 1.01 (0.79–1.28) | |||
Patient pain | 33323 (97.6) | 3 989 (12.0) | 0.66 | 0.003 | 0.48 | |||||
None | 9 563 (28.7) | 1 164 (12.2) | 1 | 4 937 (25.5) | 685 (13.9) | 1 | 1 | |||
Mild | 17 859 (53.6) | 2 139 (12.0) | 0.98 (0.91–1.06) | 10 561 (54.6) | 1 292 (12.2) | 0.87 (0.78–0.96) | 0.92 (0.82–1.03) | |||
Quite a lot | 5 224 (15.7) | 613 (11.7) | 0.96 (0.86–1.06) | 3 378 (17.5) | 392 (11.6) | 0.81 (0.71–0.93) | 0.92 (0.78–1.07) | |||
Severe | 677 (2.0) | 73 (10.8) | 0.87 (0.68–1.12) | 457 (2.4) | 46 (10.1) | 0.69 (0.51–0.95) | 0.86 (0.60–1.25) | |||
FS occurrencee | 34 139 (100) | 4 104 (12.0) | < 0.001 | - | - | |||||
First group 500 | 5 410 (15.8) | 526 (9.7) | 1 | - | - | - | - | |||
Later groups 500 | 28 729 (84.2) | 3 578 (12.5) | 1.32 (1.20–1.45) | - | - | - | - |