Prediction of survival and analysis of prognostic factors for patients with AFP negative hepatocellular carcinoma: a population-based study

Table 2 Univariate analysis and multivariate analysis of factors of overall survival (OS) of ANHC.

Variables	Categories	Univariate analysis			Multivariate analysis
Variables	Categories	HR	95% CI	P Value	HR	95% CI	P Value
Age at Diagnosis		1.026	1.02–1.033	< 0.001	1.012	1.006–1.018	< 0.001
Tumor Size		1.007	1.006–1.009	< 0.001	1.006	1.004–1.008	< 0.001
Ethnicity	African–American	1.095	0.858–1.397	0.467	0.946	0.738–1.212	0.66
	Others	0.767	0.64–0.919	0.004	0.737	0.613–0.887	0.001
Year of Diagnosis		0.852	0.729–0.997	0.046	0.807	0.688–0.948	0.009
Gender		0.996	0.836–1.188	0.967	NA	NA	NA
Grade	Grade 2	0.948	0.806–1.115	0.518	1.124	0.953–1.326	0.164
	Grade 3	1.586	1.263–1.99	< 0.001	1.984	1.574–2.501	< 0.001
	Grade 4	2.518	1.338–4.735	0.004	2.119	1.115–4.027	0.022
Surgery	LR	0.253	0.215–0.297	< 0.001	0.193	0.16–0.234	< 0.001
	LT	0.1	0.073–0.138	< 0.001	0.102	0.072–0.145	< 0.001
Chemotherapy		1.217	1.041–1.423	0.014	0.561	0.471–0.668	< 0.001
Radiation		1.445	1.057–1.977	0.021	0.641	0.463–0.887	0.007
Marital Group		0.767	0.66–0.891	0.001	0.914	0.782–1.069	0.262

Abbreviations: HR: Hazard Ratio, CI: Confidence interval, LR: Liver Resection, LT: Liver Transplant

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