Fig. 5

Succinate facilitates the EMT process through activation of STAT3/p-STAT3 in mice. (A, B) Representative lung metastatic nodules. (C, D) STAT3 and p-STAT3 expression was assessed by western blot analysis. (E, F) Protein expression of the EMT-related markers E-cadherin, N-cadherin, Vimentin, and Slug was assessed by western blot analysis. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001 compared to the controls