Table 1 Baseline characteristics of the studies included

Takahashi K

2016(15)

4w

Japan

VPZ (20 mg/d) 4w (14patients, age(yr) 71.9 ± 7.9, M/F 12/2)

Lansoprazole(30 mg/d) 4w (12patients, age(yr) 74.8 ± 8.3, M/F 10/2)

VPZ: 1/5/8

PPI: 0/4/8

Hook Knife (Olympus); Dual Knife (Olympus)

Tsuchiya I

2017(16)

8w

Japan

VPZ (20 mg/d) 8w (39patients, age(yr) 73, M/F 27/12)

Esomeprazole(20 mg/d) 8w (41patients, age(yr) 74, M/F 30/11)

VPZ: 9/13/19

PPI: 5/15/19

Triangle Tip Knife (KD-640 L; Olympus)

Hirai A

2018(17)

8w

Japan

VPZ (20 mg/d) 8w (74patients, age(yr) 73.16 ± 7.48, M/F 62/12)

Lansoprazole(30 mg/d) 8w (75patients, age(yr) 69.93 ± 11.0, M/F 55/20)

VPZ: 9/27/41

PPI: 4/29/42

Needle knife (KD-1 L; Olympus); IT Knife2 electrosurgical knife (KD-611 L; Olympus)

Ichida T

2019(22)

8w

Japan

VPZ (20 mg/d) + Rebamipide(300 mg/d) 8w (43patients, age(yr) 72.4, M/F 31/12)

Esomeprazole (20 mg/d) + Rebamipide(300 mg/d) 8w (39patients, age(yr) 73.9, M/F 34/5)

VPZ: 7/12/24

PPI: 4/18/17

Dual Knife (KD-650 L; Olympus)

Ishii Y

2018(23)

8w

Japan

VPZ (20 mg/d) + Rebamipide(300 mg/d) 8w (27patients, age(yr) 70, M/F 23/4)

Esomeprazole (20 mg/d) + Rebamipide(300 mg/d) 8w (26patients, age(yr) 70, M/F 22/4)

VPZ: 12/10/5

PPI: 14/10/2

IT knife2 (KD-611 L; Olympus); Dual Knife (KD-650U; Olympus)

Hamada K

2019(24)

8w

Japan

VPZ(20 mg/d) 8w (69patients, age(yr) 70.3 ± 6.8, M/F 51/18)

Lansoprazole(30 mg/d) 8w

(70patients, age(yr) 70.1 ± 8.5, M/F 57/13)

body/antrum VPZ: 35/34; PPI: 34/36

Insulated-tipped knife-2 (Olympus); Flush Knife (Fuji Film Medical)

Komori H

2019(25)

4w

Japan

VPZ (20 mg/d) 4w (18patients, age(yr) 69 ± 9.3, M/F 13/5)

Rabeprazole(10 mg/d) 4w (15patients, age(yr) 70.9 ± 8.8, M/F 11/4)

VPZ: 1/4/13

PPI: 2/8/5

Dual knife (KD-650 L; Olympus); IT knife-2 (KD-611 L; Olympus)

Ban H

2021(26)

8w

Japan

VPZ (20 mg/d) 8w (101patients, age(yr) 71.5 ± 8.8, M/F 76/25)

Lansoprazole(30 mg/d) 8w (95patients, age(yr) 1.2 ± 8.6, M/F 69/26)

VPZ: 8/32/61

PPI: 10/39/46

Dual knife (KD-650; Olympus)

Kawai D

2021(27)

8w

Japan

VPZ (20 mg/d) 8w (85patients, age(yr) 73, M/F 63/22)

Lansoprazole (30 mg/d) 8w

(83patients, age(yr) 73, M/F 58/25)

VPZ: 9/35/41

PPI: 11/42/30

Not applicable