Table 6 Vonoprazan-related studies in recent years
Year and Author | Treatment options | Sample size | Eradication rate | P Value | |
|---|---|---|---|---|---|
ITT | PP | ||||
2022 Yimin Lin [7] | I: VPZ 20 mg bid+AMX 750 mg qid (7 days) II: VPZ 20 mg bid+AMX 500 mg qid (7 days) III:VPZ 20 mg bid+AMX 750 mg bid+clarithromycin 500 mg (7 days) | 230 | 63.5% 58.3% 60.7% | 65.1% 66.2% 64.9% | P > 0.05 |
2022 Lifen Lu [19] | V10:VPZ20mg + AMX1.0 g + Furazolidone 100 mg + colloidal bismuth 200 mg (bid 10 days) V14:VPZ20mg + AMX1.0 g + Furazolidone 100 mg + colloidal bismuth 200 mg (bid 10 days) E14: esomilaprazole 20 mg + AMX 1.0 g + Furazolidone100 mg + colloidal bismuth 200 mg (bid 14 days) | 234 | V10: 96.2% V14:94.9% E14:93.6% | V10:98.6% V14:97.4% E14:94.8% | P > 0.05 |
2022 YI Hu [27] | VPZ 20 mg bid+AMX1.0 g Bid (7 days) VPZ20mg bid+AMX1.0 g Bid (10 days) VPZ 20 mg bid+AMX1.0 g tid (7 days) VPZ 20 mg bid+AMX1.0 g tid (10 days) | 119 | 66.7% 89.2% 81.0% 81.1% | 72.7% 89.2% 81.0% 81.1% | P > 0.05 |
2022 Wen Gao [28] | VPZ 20 mg/40 mg + AMX1.0 g tid (14 days) | 186 | 92.5% | – | |
2023 Juan Wang [29] | VPZ 20 mg + AMX 1.0 g + CLR 500 mg + colloidal bismuth 200 mg (bid 14 days) lansoprazole 30 mg / esomilaprazole 20 mg + AMX 1.0 g + CLR 500 mg + colloidal bismuth 200 mg (bid 14 days) | 340 | 88.8% 87.6% | 94.1% 91.1% | P < 0.01 |
2021 Huh [30] | VPZ 20 mg + AMX 1.0 g + CLR 500 mg + colloidal bismuth 200 mg (bid 14 days) Lansoprazole 30 mg + AMX 1.0 g + CLR500mg + colloidal bismuth 200 mg (bid 14 days) | 36 | 100% 100% | 100% 100% | P > 0.05 |
2020 Sho Suzuki [31] | VPZ 20 mg tid + AMX 750 mg tid (7 days) VPZ 20 mg tid + AMX 750 mg tid. + clarithromycin 200 mg tid(7 days) | 335 | 84.5% 89.2% | 87.1% 90.2% | P > 0.05 |
2020 William D Chey [32] | VPZ 20 mg bid+ AMX 1000 mg tid (14 days) VPZ 20 mg bid + AMX 1000 mg bid. + clarithromycin 500 mg bid(14 days) lansoprazole 30 mg bid + AMX 100 mg bid. + clarithromycin 500 mg bid(14 days) | 1046 | 78.5% 84.7% 78.8% | 81.2% 90.4% 82.1% | P < 0.01 (ITT) P = 0.016(PP) |
2021 Chalermrat Bunchorntavakul [33] | VPZ 20 mg bid+ AMX 1000 mg bid. + clarithromycin 500 mg bid(7 days) VPZ 20 mg bid+ AMX 1000 mg bid. + clarithromycin 500 mg bid(14 days) | 122 | 96.7% 88.5% | 98.3% 93.1% | P > 0.05 |