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  1. We previously reported that two differentially methylated region (DMR) networks identified by DMR and co-methylation analyses are strongly correlated with the fibrosis stages of nonalcoholic fatty liver diseas...

    Authors: Suguru Kurokawa, Masato Yoneda, Yuji Ogawa, Yasushi Honda, Takaomi Kessoku, Kento Imajo, Satoru Saito, Atsushi Nakajima and Kikuko Hotta
    Citation: BMC Gastroenterology 2022 22:278
  2. Acute esophageal necrosis (AEN), commonly referred to as Gurvits syndrome or “black esophagus”, is a rare clinical disease. We present a case of AEN associated with diabetic ketoacidosis (DKA).

    Authors: Daisuke Kitawaki, Atsushi Nishida, Keitaro Sakai, Yuji Owaki, Kyohei Nishino, Yoshika Noda and Hirotsugu Imaeda
    Citation: BMC Gastroenterology 2022 22:277
  3. Underwater endoscopic mucosal resection (UMER) is a new method of endoscopic resection to completely remove the lesion without submucosal injection. But few attempts have been carried out for rectal neuroendoc...

    Authors: Haitao Shi, Chuying Wang, Jie Wu, Bin Qin, Jiong Jiang, Na Liu, Yahua Song, Yun Qin and Shiyang Ma
    Citation: BMC Gastroenterology 2022 22:276
  4. Patients with hepatocellular carcinoma (HCC) and macrovascular invasion (MVI) who receive systemic chemotherapy have a poor prognosis. This study aimed to determine if one-shot cisplatin (CDDP) chemotherapy vi...

    Authors: Kensuke Naruto, Tomokazu Kawaoka, Kenichiro Kodama, Yutaro Ogawa, Kei Amioka, Yuki Yoshikawa, Chihiro Kikukawa, Yousuke Suehiro, Kenji Yamaoka, Yuwa Ando, Yumi Kosaka, Shinsuke Uchikawa, Takashi Nakahara, Eisuke Murakami, Atsushi Ono, Takuro Uchida…
    Citation: BMC Gastroenterology 2022 22:275
  5. I-125 seeds brachytherapy (ISB) has been used to improve the clinical effectiveness of transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC). We aim to appraise the safety and clinical effi...

    Authors: Fu-Lei Gao, Yong Wang, Xiang-Zhong Huang, Tian-Fan Pan and Jin-He Guo
    Citation: BMC Gastroenterology 2022 22:273
  6. Pneumatosis intestinalis (PI) is a rare condition characterized by gas collection in the intestinal wall. We aimed to determine the etiology and affected segments associated with complications, treatment, and ...

    Authors: Naoki Ohmiya, Ichiro Hirata, Hirotsugu Sakamoto, Toshifumi Morishita, Eiko Saito, Katsuyoshi Matsuoka, Tadanobu Nagaya, Shinji Nagata, Miyuki Mukae, Koji Sano, Takayoshi Suzuki, Ken-ichi Tarumi, Seiji Shimizu, Kousaku Kawashima and Toshifumi Hibi
    Citation: BMC Gastroenterology 2022 22:272
  7. Nafamostat mesilate decreases the incidence of pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP). However, no studies have administered nafamostat mesilate after ERCP. So we investigated...

    Authors: Joo Seong Kim, Sang Hyub Lee, Namyoung Park, Gunn Huh, Jung Won Chun, Jin Ho Choi, In Rae Cho, Woo Hyun Paik, Ji Kon Ryu and Yong-Tae Kim
    Citation: BMC Gastroenterology 2022 22:271
  8. Serum hepatitis B surface antigen (HBsAg) is a component of both hepatitis B virus (HBV) virions and non-infectious subviral particles (SVPs). Recently, O-glycosylation of the PreS2 domain of middle HBsAg protein...

    Authors: Ayato Murata, Kiyohiko Angata, Maki Sogabe, Shunsuke Sato, Takafumi Ichida, Hisashi Narimatsu and Takuya Genda
    Citation: BMC Gastroenterology 2022 22:270
  9. Intrahepatic cholangiocarcinoma (ICC) is the second most common primary hepatic malignancy with poor prognosis. Intrahepatic bile duct stone (IBDS) is one of the key causes to ICC occurrence and can increase m...

    Authors: Jun Li, Jiongjiong Lu, Shaodong Lv, Shujun Sun, Caifeng Liu, Feng Xu, Haiying Sun, Jiamei Yang, Xinjun Wang, Xingyang Zhong and Junhua Lu
    Citation: BMC Gastroenterology 2022 22:269
  10. Anti-TNF therapy represented a landmark in medical treatment of ulcerative colitis (UC). There is lack of data on the efficacy and safety of these agents in Brazilian patients. The present study aimed to analy...

    Authors: Ligia Yukie Sassaki, Daniela Oliveira Magro, Rogerio Saad-Hossne, Julio Pinheiro Baima, Cristina Flores, Lucianna Motta Correia, Lívia Medeiros Soares Celani, Maria De Lourdes De Abreu Ferrari, Patricia Zacharias, Marley Ribeiro Feitosa, Carlos Henrique Marques Dos Santos, Manoel Alvaro De Freitas Lins Neto, Abel Botelho Quaresma, Sergio Figueiredo De Lima Junior, Graciana Bandeira Salgado De Vasconcelos, Ornella Sari Cassol…
    Citation: BMC Gastroenterology 2022 22:268
  11. Potential dietary inflammation can precursor chronic diseases such as hepatic disorders. We aimed to examine the association of empirical dietary inflammatory patterns (EDIP) and dietary inflammation scores (D...

    Authors: Hossein Farhadnejad, Asal Neshatbini Tehrani, Mitra Kazemi Jahromi, Farshad Teymoori, Ebrahim Mokhtari, Ammar Salehi-Sahlabadi and Parvin Mirmiran
    Citation: BMC Gastroenterology 2022 22:267
  12. Fatty liver index (FLI) is the most recognized blood biomarker for diagnosis of hepatic steatosis (HS), but lacks the reliable specific cut-off points (COPs). Therefore, we aim to investigate the population-sp...

    Authors: Juan Wu, Shen Tian, Hao Li, Zhou Xu, Shu Li, Yu-ling Chen, Xin-yu Liang, Jun Xiao, Jing-yu Song, Rui-ling She, Chen-yu Ma, Jun-han Feng, Zhao-xing Li, Zhi-yu Jiang, Zi-wei Zhang, Kai-nan Wu…
    Citation: BMC Gastroenterology 2022 22:265
  13. The use of ROSE in EUS-FNA pancreatic lesions is still controversial in many centers. In this study, we aimed to demonstrate the contribution of ROSE to the diagnostic accuracy, as well as its assistance to th...

    Authors: Irem Guvendir, Itir Ebru Zemheri and Kamil Ozdil
    Citation: BMC Gastroenterology 2022 22:264
  14. The frequency and intensity of natural disasters are increasing worldwide, which makes our understanding of disaster-related diseases more important than ever. Natural disasters cause mental stress and infecti...

    Authors: Yuji Okazaki, Shuhei Yoshida, Saori Kashima, Daisuke Miyamori and Masatoshi Matsumoto
    Citation: BMC Gastroenterology 2022 22:263
  15. Diverticulosis of the appendix is an uncommon clinical entity, and a preoperative diagnosis is often difficult. Herein we report an unusual case of appendiceal diverticulosis.

    Authors: Toshihisa Kimura, Takanori Goi, Yuki Kidoguchi, Kenji Ohnishi, Tamotsu Togawa, Atsushi Iida and Yasunori Sato
    Citation: BMC Gastroenterology 2022 22:262
  16. Systemic inflammatory response (SIR) plays a crucial role in every step of tumorigenesis and development. More recently, the fibrinogen-to-albumin ratio (FAR), an inflammation-based model, was suggested as a p...

    Authors: Rong-yun Mai, Tao Bai, Xiao-ling Luo and Guo-bin Wu
    Citation: BMC Gastroenterology 2022 22:261
  17. There is a clinical need to develop biomarkers of small bowel damage in coeliac disease and Crohn’s disease. This study evaluated intestinal fatty acid binding protein (iFABP), a potential biomarker of small b...

    Authors: Michael Logan, Mary MacKinder, Clare Martha Clark, Aikaterini Kountouri, Mwansa Jere, Umer Zeeshan Ijaz, Richard Hansen, Paraic McGrogan, Richard K. Russell and Konstantinos Gerasimidis
    Citation: BMC Gastroenterology 2022 22:260
  18. Endocytoscopy (ECS) enables microscopic observation in vivo for the gastrointestinal mucosa; however, there has been no prospective study in which the diagnostic accuracy of ECS for lesions that have not yet u...

    Authors: Yoshihiko Shimoda, Yuichi Shimizu, Hiroaki Takahashi, Satoshi Okahara, Takakazu Miyake, Shin Ichihara, Ikko Tanaka, Masaki Inoue, Sayoko Kinowaki, Masayoshi Ono, Keiko Yamamoto, Shoko Ono and Naoya Sakamoto
    Citation: BMC Gastroenterology 2022 22:259
  19. Colon capsule endoscopy (CCE) is a non-invasive alternative to colonoscopy. The reported sensitivity and specificity of CCE for the detection of clinically significant colonic neoplasia is high. To date, there...

    Authors: C. MacLeod, R. Oliphant, J. G. Docherty and A. J. M. Watson
    Citation: BMC Gastroenterology 2022 22:258
  20. Metallic stents placed in the descending duodenum can cause compression of the major duodenal papilla, resulting in biliary obstruction and pancreatitis. These are notable early adverse events of duodenal sten...

    Authors: Junichi Kaneko, Hirotoshi Ishiwatari, Koiku Asakura, Tatsunori Satoh, Junya Sato, Kazuma Ishikawa, Hiroyuki Matsubayashi, Yohei Yabuuchi, Yoshihiro Kishida, Masao Yoshida, Sayo Ito, Noboru Kawata, Kenichiro Imai, Kohei Takizawa, Kinichi Hotta and Hiroyuki Ono
    Citation: BMC Gastroenterology 2022 22:257
  21. Guidelines on colorectal cancer (CRC) screening recommend screening of average-risk adults only. In addition, screening of individuals with active inflammatory bowel disease (IBD) might result in too many fals...

    Authors: Pernille Thordal Larsen, Susanne Fogh Jørgensen and Sisse Helle Njor
    Citation: BMC Gastroenterology 2022 22:256
  22. For patients with gastro-oesophageal reflux symptoms, the preferred treatment is proton pump inhibitor (PPI) administration for approximately 8 weeks. However, long-term use of PPIs can cause gut microbiome (G...

    Authors: Wenjun Liu, Yong Xie, Yingmeng Li, Longjin Zheng, Qiuping Xiao, Xu Zhou, Qiong Li, Ni Yang, Kexuan Zuo, Tielong Xu, Nong-Hua Lu and Heping Zhang
    Citation: BMC Gastroenterology 2022 22:255
  23. Achalasia is a rare primary esophageal motility disorder disease. It is reported that the long-term effect of fully coated anti-reflux metal stent (FCARMS) implantation is satisfactory. Operated by a skilled a...

    Authors: Yu-fen Tang, Peng Jin, Yu-rong Tao, Hui Xie, Xin Wang, Dongliang Yu, Shan Tang and Jian-qiu Sheng
    Citation: BMC Gastroenterology 2022 22:253
  24. Intestinal ultrasound (IUS) is an increasingly used non-invasive tool to evaluate Crohn’s disease (CD) activity. Recently, two IUS scores that evaluate inflammatory activity have emerged: the Simple Ultrasound...

    Authors: M. Freitas, F. Dias de Castro, V. Macedo Silva, C. Arieira, T. Cúrdia Gonçalves, S. Leite, M. J. Moreira and J. Cotter
    Citation: BMC Gastroenterology 2022 22:252
  25. Transition in care is defined as the “purposeful and planned movement of adolescents and young adults with a chronic medical condition from pediatric to adult-oriented healthcare systems/care providers.” Curre...

    Authors: Natasha Bollegala, Melanie Barwick, Nancy Fu, Anne M. Griffiths, Laurie Keefer, Sara Ahola Kohut, Karen I. Kroeker, Sally Lawrence, Kate Lee, David R. Mack, Thomas D. Walters, Jacqueline de Guzman, Claudia Tersigni, Ashleigh Miatello and Eric I. Benchimol
    Citation: BMC Gastroenterology 2022 22:251
  26. It is crucial to manage the recurrence of Crohn’s disease (CD). This study is aimed to explore whether visceral adipose tissue (VAT) and skeletal muscle (SM) are associated with the recurrence of CD upon diffe...

    Authors: Zinan Zhang, Xiaoyu Yu, Ning Fang, Xiuyan Long, Xixian Ruan, Jianing Qiu, Sifan Tao, Pan Gong, Kai Nie, An Li, Xiaoyan Wang and Li Tian
    Citation: BMC Gastroenterology 2022 22:250
  27. Perforation and obstruction in colorectal cancer are poor prognostic factors. We aimed to evaluate the oncological outcomes of patients with colon cancer presenting with perforation or obstruction.

    Authors: Kwan Mo Yang, Min-Jae Jeong, Kwang Hyun Yoon, Yun Tae Jung and Jae Young Kwak
    Citation: BMC Gastroenterology 2022 22:247
  28. Calcification of abdominal lymph node is a common clinical phenomenon, but it is extremely rare to cause serious adverse clinical outcomes. In the present case, the ruptured hemorrhage of the oesophagogastric ...

    Authors: Shuming Liu, Xingwu Xie, Xianzhi Tang, Huan He, Huiyuan Guan and Guangbin Chen
    Citation: BMC Gastroenterology 2022 22:245
  29. Increased pancreatic cancer incidence has been observed among younger than in older adults. This pilot study aimed to determine the feasibility of a large study that would compare the age at diagnosis of pancr...

    Authors: Ro-Ting Lin, Pei-Lung Chen, Chi-Ying Yang, Chun-Chieh Yeh, Chun-Che Lin, Wen-Hsin Huang, An-Ko Chung and Jaw-Town Lin
    Citation: BMC Gastroenterology 2022 22:243
  30. Fatty liver is frequently found in a general population, and it is critical to detect advanced fibrosis. FIB-4 index is considered a useful marker for evaluating liver fibrosis but the distribution of FIB-4 in...

    Authors: Aya Sugiyama, Akemi Kurisu, Bunthen E, Serge Ouoba, Ko Ko, Anvarjon Rakhimov, Tomoyuki Akita, Takayuki Harakawa, Toru Sako, Makoto Koshiyama, Takashi Kumada and Junko Tanaka
    Citation: BMC Gastroenterology 2022 22:241
  31. Urinary and faecal metabolic profiling have been extensively studied in gastrointestinal diseases as potential diagnostic markers, and to enhance our understanding of the intestinal microbiome in the pathogene...

    Authors: Sam T. R. Powles, Kate I. Gallagher, Leo W. L. Chong, James L. Alexander, Benjamin H. Mullish, Lucy C. Hicks, Julie A. K. McDonald, Julian R. Marchesi, Horace R. T. Williams and Timothy R. Orchard
    Citation: BMC Gastroenterology 2022 22:240
  32. Low anterior resection syndrome (LARS) is the most common complication after rectal cancer resection. We aimed to identify LARS' predictive factors and construct and evaluate a predictive model for LARS.

    Authors: Masakatsu Paku, Norikatsu Miyoshi, Shiki Fujino, Tsuyoshi Hata, Takayuki Ogino, Hidekazu Takahashi, Mamoru Uemura, Tsunekazu Mizushima, Hirofumi Yamamoto, Yuichiro Doki and Hidetoshi Eguchi
    Citation: BMC Gastroenterology 2022 22:239
  33. Studies have confirmed the prognostic value of the expression status of human epidermal growth factor receptor 2 (HER2) in advanced gastric cancer. However, its role in early gastric cancer (EGC) remains large...

    Authors: Hui Li, Longsong Li, Nan Zhang, Zixin Wang, Ning Xu, Enqiang Linghu and Ningli Chai
    Citation: BMC Gastroenterology 2022 22:238
  34. Endocytoscopy (ECS) aids early gastric cancer (EGC) diagnosis by visualization of cells. However, it is difficult for non-experts to accurately diagnose EGC using ECS. In this study, we developed and evaluated...

    Authors: Hiroto Noda, Mitsuru Kaise, Kazutoshi Higuchi, Eriko Koizumi, Keiichiro Yoshikata, Tsugumi Habu, Kumiko Kirita, Takeshi Onda, Jun Omori, Teppei Akimoto, Osamu Goto, Katsuhiko Iwakiri and Tomohiro Tada
    Citation: BMC Gastroenterology 2022 22:237
  35. Capsule endoscopy (CE) provides a novel approach to evaluate obscure gastrointestinal bleeding. Yet CE is not routinely utilized in the inpatient setting for a variety of reasons. We sought to identify factors...

    Authors: Irving Levine, Soonwook Hong, Dimpal Bhakta, Matthew B. McNeill, Seth A. Gross and Melissa Latorre
    Citation: BMC Gastroenterology 2022 22:236
  36. Authors: Chang Hong, Chengkai Wu, Pengcheng Ma, Hao Cui, Liya Chen, Ruining Li, Qimei Li, Lin Zeng, Shengwu Liao, Lushan Xiao, Li Liu and Wenyuan Li
    Citation: BMC Gastroenterology 2022 22:235

    The original article was published in BMC Gastroenterology 2022 22:185

  37. Aberrations in cyclooxygenase and lipoxygenase (LOX) pathways in non-neoplastic, normal appearing mucosa from patients with colorectal neoplasia (CRN), could hypothetically qualify as predisposing CRN-markers.

    Authors: Ulrike Ries Feddersen, Sebastian Kjærgaard Hendel, Mark Alexander Berner-Hansen, Thomas Andrew Jepps, Mark Berner-Hansen and Niels Bindslev
    Citation: BMC Gastroenterology 2022 22:234

    The Correction to this article has been published in BMC Gastroenterology 2022 22:298

  38. Adipokines such as leptin, visfatin and chemerin play a pivotal role not only in the pathogenesis of excessive weight gain but also impact on hepatic metabolism. However, alterations in the production of these...

    Authors: I. Kasacka, Ż. Piotrowska, N. Domian, A. Lewandowska and M. Acewicz
    Citation: BMC Gastroenterology 2022 22:233
  39. The detection rate of methylated Septin9 (mSEPT9) in colorectal cancer (CRC) is varied greatly across the studies. This study aimed to evaluate the diagnostic ability of mSEPT9 in CRC, and compare the diagnost...

    Authors: Dong-cheng Lu, Qi-fang Zhang, Li Li, Xian-ke Luo, Bin Liang, Yi-han Lu, Bang-li Hu and Hai-xing Jiang
    Citation: BMC Gastroenterology 2022 22:232
  40. Acute kidney injury (AKI) is a common and life-threatening complication of liver failure. The purpose of this study is to construct a nomogram and online calculator to predict the development of hospital-acqui...

    Authors: Yue Huang, Junjun Cai, Fushuang Ha, Beichen Guo, Shaojie Xin, Zhongping Duan and Tao Han
    Citation: BMC Gastroenterology 2022 22:231
  41. Mucosal healing (MH) has become the treatment goal of patients with Crohn’s disease (CD). This study aims to develop a noninvasive and reliable clinical tool for individual evaluation of mucosal healing in pat...

    Authors: Nana Tang, Han Chen, Ruidong Chen, Wen Tang and Hongjie Zhang
    Citation: BMC Gastroenterology 2022 22:229
  42. Entecavir (ETV) can suppress chronic hepatitis B (CHB) virus replication as a standard of treatment drugs. For the treatment of CHB, affordable generic drugs may be more widely used in developing and undevelop...

    Authors: Po-Ke Hsu, Pei-Yuan Su and Chia-Lin Wu
    Citation: BMC Gastroenterology 2022 22:228

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